INSTITUT FÜR MEDIZINISCHE MIKROBIOLOGIE UND KRANKENHAUSHYGIENE

Publikationen

2020

Wedekind A, Fritzsch D, Kröger A.
Add on the next level-the time point of the type I IFN response orchestrates the immune response.
Cell Mol Immunol. 2020 Apr 28. doi: 10.1038/s41423-020-0442-7. Online ahead of print.Cell Mol Immunol. 2020. PMID: 32346100 No abstract available.

2019

Prochnow H, Rox K, Birudukota NVS, Weichert L, Hotop SK, Klahn P, Mohr K, Franz S, Banda DH, Blockus S, Schreiber J, Haid S, Oeyen M, Martinez JP, Süssmuth RD, Wink J, Meyerhans A, Goffinet C, Messerle M, Schulz TF, Kröger A, Schols D, Pietschmann T, Brönstrup M.
Labyrinthopeptins exert broad-spectrum antiviral activity through lipid-binding-mediated virolysis.
J Virol. 2019 Oct 30. pii: JVI.01471-19. doi: 10.1128/JVI.01471-19. [Epub ahead of print]

Ring S, Eggers L, Behrends J, Wutkowski A, Schwudke D, Kröger A, Hierweger AM, Hölscher C, Gabriel G, Schneider BE.
Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation.
JCI Insight. 2019 Apr 18;5. pii: 126533. doi: 10.1172/jci.insight.126533.

Büssow K, Themann P, Luu S, Pentrowski P, Harting C, Majewski M, Vollmer V, Köster M, Grashoff M, Zawatzky R, Van den Heuvel J, Kröger A, Böldicke T.
ER intrabody-mediated inhibition of interferon α secretion by mouse macrophages and dendritic cells.
PLoS One. 2019 Apr 16;14(4):e0215062. doi: 10.1371/journal.pone.0215062. eCollection 2019.

Heyner M, Schreier S, Kröger A.
The brain-immune cells axis controls tissue specific immunopathology.
Cell Mol Immunol. 2019 Feb;16(2):101-103. doi: 10.1038/s41423-018-0176-y. Epub 2018 Nov 7.

2018

Heyner M, Schreier S, Kröger A.
The brain-immune cells axis controls tissue specific immunopathology.
Cell Mol Immunol. 2018 Nov 7. doi: 10.1038/s41423-018-0176-y. [Epub ahead of print]

Kurhade C, Schreier S, Lee YP, Zegenhagen L, Hjertqvist M, Dobler G, Kröger A, Överby AK.
Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice.
Emerg Infect Dis. 2018 Sep;24(9):1709-1712. doi: 10.3201/eid2409.171825.

2017

Eyer L, Kondo H, Zouharova D, Hirano M, Valdés JJ, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Kröger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, De Clercq E, Yoshii K, Ruzek D.
Escape of tick-borne flavivirus from 2' -C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness.
J Virol. 2017 Aug 16. pii: JVI.01028-17. doi: 10.1128/JVI.01028-17. [Epub ahead of print]

Kröger A.
IRFs as competing pioneers in T-cell differentiation. C
ell Mol Immunol. 2017 Aug;14(8):649-651. doi: 10.1038/cmi.2017.37. Epub  2017 Jun 19.

Somplatzki S, Mühlenhoff M, Kröger A, Gerardy-Schahn R, Böldicke T.
Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells.
BMC Biotechnol. 2017 May 12;17(1):42. doi: 10.1186/s12896-017-0360-7.

2016

Asghar N, Lee YP, Nilsson E, Lindqvist R, Melik W, Kröger A, Överby AK, Johansson M.
The role of the poly(A) tract in the replication and virulence of tick-borne encephalitis virus.
Sci Rep. 2016 Dec 16;6:39265. doi: 10.1038/srep39265.

Zegenhagen L, Kurhade C, Kröger A, Overby AK.
Differences in IPS-1-Mediated Innate Immune Responses between Neurotrophic Flavivirus Infection.
J Neuroinfect Dis. 2016 7(1).

Lindqvist R, Mundt F, Gilthorpe JD, Wölfel S, Gekara NO, Kröger A, Överby AK.
Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects.
J Neuroinflammation. 2016 Oct 24;13(1):277.

Andzinski L, Spanier J, Kasnitz N, Kröger A, Jin L, Brinkmann MM, Kalinke U, Weiss S, Jablonska J, Lienenklaus S.
Growing tumors induce a local STING dependent type I IFN response in dendritic cells.
Int J Cancer. 2016 Sep 15;139(6):1350-7. doi: 10.1002/ijc.30159.

Stegemann-Koniszewski S, Jeron A, Gereke M, Geffers R, Kröger A, Gunzer M, Bruder D.
Alveolar type II epithelial cells contribute to the anti-influenza A virus response in the lung by integrating pathogen- and microenvironment-derived signals.
mBio 7(3):e00276-16. doi:10.1128/mBio.00276-16.

Zegenhagen L, Kurhade C, Koniszewski N, Överby AK, Kröger A.
Brain heterogeneity leads to differential innate immune responses and modulates pathogenesis of viral infections.
Cytokine Growth Factor Rev. 2016 Aug;30:95-101. doi: 10.1016/j.cytogfr.2016.03.006.

Castiglia V, Piersigilli A, Ebner F, Janos M, Goldmann O, Damböck U, Kröger A, Weiss S, Knapp S, Jamieson AM, Kirschning C, Kalinke U, Strobl B, Müller M, Stoiber D, Lienenklaus S, Kovarik P.
Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue.
Cell Host Microbe. 2016 Mar 9;19(3):375-87. doi: 10.1016/j.chom.2016.02.003.

Nocera DA, Roselli E, Araya P, Nuñez NG, Lienenklaus S, Jablonska J, Weiss S, Gatti G, Brinkmann MM, Kröger A, Morón G, Maccioni M.
In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration.
J Immunol. 2016 Mar 15;196(6):2860-9. doi: 10.4049/jimmunol.1501044. Epub 2016 Feb 15.

Kurhade C, Zegenhagen L, Weber E, Nair S, Michaelsen-Preusse K, Spanier J, O Gekara N, Kröger A#, Överby AK#.
Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.
J Neuroinflammation. 2016 13:22 doi: 10.1186/s12974-016-0487-9 #:contributed equally

2015

Marandu TF, Oduro JD, Borkner L, Dekhtiarenko I, Uhrlaub JL, Drabig A, Kröger A, Nikolich-Zugich J, Cicin-Sain L.
Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.
J Virol. 2015 Nov 15;89(22):11715-7. doi: 10.1128/JVI.01989-15. Epub 2015 Sep 2.

Andzinski L, Wu CF, Lienenklaus S, Kröger A, Weiss S, Jablonska J.
Delayed apoptosis of tumor associated neutrophils in the absence of endogenous IFN-β.
Int J Cancer. 2015 Feb 1;136(3):572-83. doi: 10.1002/ijc.28957. Epub 2014 May 16.

Härtlova A, Erttmann SF, Raffi FA, Schmalz AM, Resch U, Anugula S, Lienenklaus S, Nilsson LM, Kröger A, Nilsson JA, Ek T, Weiss S, Gekara NO.
DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity.
Immunity. 2015 Feb 17;42(2):332-43. doi: 10.1016/j.immuni.2015.01.012.

Wu CF, Andzinski L, Kasnitz N, Kröger A, Klawonn F, Lienenklaus S, Weiss S, Jablonska J.
The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung.
Int J Cancer. 2015 Aug 15;137(4):837-47. doi: 10.1002/ijc.29444. Epub 2015 Feb 5.

2014

Nair S, Michaelsen-Preusse K, Finsterbusch K, Stegemann-Koniszewski S, Bruder D, Grashoff M, Korte M, Köster M, Kalinke U, Hauser H, Kröger A. Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons.
PLoS Pathog. 2014 Mar 27;10(3):e1003999.

Weber E, Finsterbusch K, Lindquis R, Nair S, Lienenklaus S, Gekara NO, Janik D, Weiss S, Kalinke U, Överby AK, Kröger A.
Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses.
J Virol. 2014 Nov;88(21):12202-12. doi: 10.1128/JVI.01215-14. Epub 2014 Aug 13

Spanier J, Lienenklaus S, Paijo J, Kessler A, Borst K, Heindorf S, Baker DP, Kröger A, Weiss S, Detje CN, Staeheli P, Kalinke U.
Concomitant TLR/RLH signaling of radioresistant and radiosensitive cells is essential for protection against vesicular stomatitis virus infection.
J Immunol. 2014 Sep 15;193(6):3045-54. doi: 10.4049/jimmunol.1400959. Epub 2014 Aug 15.

Andzinski L, Wu CF, Lienenklaus S, Kröger A, Weiss S, Jablonska J.
Delayed apoptosis of tumor associated neutrophils in the absence of endogenous IFN-β.
Int J Cancer. 2014 May 8. doi: 10.1002/ijc.28957.

Frentzen A, Anggakusuma, Gurlevik E, Hueging K,  Knocke S, Ginkel C, Brown RJ, Heim M, Dill MT, Kröger A, Kalinke U, Kaderali L, Kuehnel F,  Pietschmann T.
Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells.
Hepatology (Baltimore, Md.) 2014 59: 78-88.

Marandu, T. F., K. Finsterbusch, A. Kröger, and L. Cicin-Sain. 2014.
Mouse CMV infection delays antibody class switch upon an unrelated virus challenge.
Exp Gerontol. pii: S0531-5565(14)00029-1

2013

Nandakumar R, Finsterbusch K, Lipps C, Neumann B, Grashoff M, Nair S, Hochnadel I, Lienenklaus S, Wappler I, Steinmann E, Hauser H, Pietschmann T, Kröger A. 
Hepatitis C Virus Replication in Mouse Cells Is Restricted by IFN-Dependent and -Independent Mechanisms.
Gastroenterology 2013 145:1414-1423 e1411.

2012

Ksienzyk A, Neumann B, Kröger A.
IRF-1 is critical for IFNgamma mediated immune surveillance.
Oncoimmunology 2012 1:533-534.

Rand U, Rinas M, Schwerk J, Nohren G, Linnes M, Kröger A, Flossdorf M, Kaly-Kullai K, Hauser H, Hofer T, Koster M.
Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response.
Mol Syst Biol. 2012 May 22;8:584

2011

Ksienzyk A, Neumann B, Nandakumar R, Finsterbusch K, Grashoff M, Zawatzky R, Bernhardt G, Hauser H, Kröger, A.
IRF-1 expression is essential for natural killer cells to suppress metastasis.
Cancer Res. 2011 Oct 15;71(20):6410-8.

2010

Dietrich N, Rohde M, Geffers R, Kröger A, Hauser H, Weiss S, Gekara NO.
Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria.
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8748-53.

Stirnweiss A, Ksienzyk A, Klages K, Rand U, Grashoff M, Hauser H, Kröger A.
IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.
J Immunol. 2010 May 1;184(9):5179-85.

2009

Probst-Kepper M*, Geffers R*, Kröger A*, Viegas N, Erck C,  Hecht HJ, Lunsdorf H, Roubin R, Moharregh-Khiabani D, Wagner K, Ocklenburg F, Jeron A, Garritsen H, Arstila TP, Kekalainen E, Balling R, Hauser H, Buer J, Weiss S.
GARP: a key receptor controlling FOXP3 in human regulatory T cells.
J Cell Mol Med. 2009 Sep;13(9B):3343-57.* contributed equally.

Stegemann S, Dahlberg A, Kröger A, Gereke M, Bruder D, Henriques-Normark B, Gunzer M.
Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia.
PLoS One. 2009;4(3):e4840.

Probst-Kepper M, Kröger A, Garritsen HS, Buer J.
Perspectives on Regulatory T Cell Therapies.
Transfus Med Hemother. 2009;36(5):302-308.

2008

Bochtler P, Kröger A, Schirmbeck R,  Reimann J.
Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells.
J Immunol. 2008 Aug 1;181(3):1633-43.

2007

Kröger A, Stirnweiss A, Pulverer JE, Klages K, Grashoff M, Reimann J, Hauser H.
Tumor suppression by IFN regulatory factor-1 is mediated by transcriptional down-regulation of cyclin D1.
Cancer Res. 2007 Apr 1;67(7):2972-81.

Ramsauer, K., M. Farlik, G. Zupkovitz, C. Seiser, A. Kröger, H. Hauser, and T. Decker.
Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene.
Proc Natl Acad Sci U S A
. 2007 Feb 20;104(8):2849-54.

2006

Schirmbeck R, Riedl P, Kupferschmitt M, Wegenka U, Hauser H, Rice J, Kröger A, Reimann J.
Priming protective CD8 T cell immunity by DNA vaccines encoding chimeric, stress protein-capturing tumor-associated antigen.
J Immunol. 2006 Aug 1;177(3):1534-42.

Froese N, Schwarzer M, Niedick I, Frischmann U, Koster M, Kröger A, Mueller PP, Nourbakhsh M, Pasche B, Reimann J, Staeheli P, Hauser H. 
Innate immune responses in NF-kappaB-repressing factor-deficient mice.
Mol Cell Biol. 2006 Jan;26(1):293-302.

2005

May T, Mueller PP, Weich H, Froese N, Deutsch U, Wirth D, Kröger A, Hauser H.
Establishment of murine cell lines by constitutive and conditional immortalization.
J Biotechnol. 2005 Oct 17;120(1):99-110.

Dikopoulos N, Bertoletti A, Kröger A, Hauser H, Schirmbeck R, Reimann J.
Type I IFN negatively regulates CD8+ T cell responses through IL-10-producing CD4+ T regulatory 1 cells.
J Immunol. 2005 Jan 1;174(1):99-109.

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