INSTITUT FÜR MEDIZINISCHE MIKROBIOLOGIE UND KRANKENHAUSHYGIENE

Publikationen des Instituts

2020

Bruder D. 
Influenza – Prävalenz, Bedeutung und Implikationen für die Prävention und Gesundheitsförderung.
In: Tiemann M., Mohokum M. (eds) Prävention und Gesundheitsförderung. Springer Reference Pflege – Therapie – Gesundheit. Springer, Berlin, Heidelberg (2020) https://doi.org/10.1007/978-3-662-55793-8_68-1

Wedekind A, Fritzsch D, Kröger A.
Add on the next level-the time point of the type I IFN response orchestrates the immune response.
Cell Mol Immunol. 2020 Apr 28. doi: 10.1038/s41423-020-0442-7. Online ahead of print.Cell Mol Immunol. 2020. PMID: 32346100 No abstract available.

Sasaki K, Bruder D, Hernandez-Vargas E.
Topological data analysis to model the shape of immune responses during co-infections.
Commun Nonlinear Sci Numer Simulat 85 (2020) 105228. Epub ahead of print.

Böning MAL, Trittel S, Riese P, van Ham M, Heyner M, Voss M, Parzmair GP, Klawonn F, Jeron A, Guzman CA, Jänsch L, Schraven B, Reinhold A, Bruder D.
ADAP promotes degranulation and migration of NK cells primed during in vivo Listeria monocytogenes infection in mice.
Front Immunol. 2020 Jan 22; doi.org/10.3389/fimmu.2019.03144

Aghapour M, Remels AHV, Pouwels SD, Bruder D, Hiemstra PS, Cloonan SM, Heijink IH.
Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol.
2020 Jan 1;318(1):L149-L164. doi: 10.1152/ajplung.00329.2019. Epub 2019 Nov 6.

2019

Frentzel S, Katsoulis-Dimitriou K, Jeron A, Schmitz I, Bruder D.
Essential role of IκBNS for in vivo CD4+ T-cell activation, proliferation, and Th1-cell differentiation during Listeria monocytogenes infection in mice.
Eur J Immunol
. 2019 Sep;49(9):1391-1398. doi: 10.1002/eji.201847961. Epub 2019 Jun 7

Prochnow H, Rox K, Birudukota NVS, Weichert L, Hotop SK, Klahn P, Mohr K, Franz S, Banda DH, Blockus S, Schreiber J, Haid S, Oeyen M, Martinez JP, Süssmuth RD, Wink J, Meyerhans A, Goffinet C, Messerle M, Schulz TF, Kröger A, Schols D, Pietschmann T, Brönstrup M.
Labyrinthopeptins exert broad-spectrum antiviral activity through lipid-binding-mediated virolysis.
J Virol. 2019 Oct 30. pii: JVI.01471-19. doi: 10.1128/JVI.01471-19. [Epub ahead of print] 


Behrens-Baumann WJ, Hofmüller W, Tammer I, Tintelnot K.
Keratomycosis due to Tintelnotia destructans refractory to common therapy treated successfully with systemic and local terbinafine in combination with polyhexamethylene biguanide. 
Int Ophthalmol. 2019 Jun;39(6):1379-1385. doi: 10.1007/s10792-018-0930-2.

Ring S, Eggers L, Behrends J, Wutkowski A, Schwudke D, Kröger A, Hierweger AM, Hölscher C, Gabriel G, Schneider BE.
Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation.
JCI Insight. 2019 Apr 18;5. pii: 126533. doi: 10.1172/jci.insight.126533.

Yi W, Schlüter D, Wang X.
Astrocytes in multiple sclerosis and experimental autoimmune encephalomyelitis: Star-shaped cells illuminating the darkness of CNS autoimmunity. 
Brain Behav Immun. 2019 Aug;80:10-24. doi: 10.1016/j.bbi.2019.05.029. Epub  2019 May 21.

Büssow K, Themann P, Luu S, Pentrowski P, Harting C, Majewski M, Vollmer V, Köster M, Grashoff M, Zawatzky R, Van den Heuvel J, Kröger A, Böldicke T.
ER intrabody-mediated inhibition of interferon α secretion by mouse macrophages and dendritic cells.
PLoS One. 2019 Apr 16;14(4):e0215062. doi: 10.1371/journal.pone.0215062. eCollection 2019.

Zheng X, Oduro JD, Boehme JD, Borkner L, Ebensen T, Heise U, Gereke M, Pils MC, Krmpotic A, Guzmán CA, Bruder D, Čičin-Šain L.
Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge.
PLoS Pathog. 2019 Sep 16;15(9):e1008036.

Sharma-Chawla N, Stegemann-Koniszewski S, Christen H, Boehme JD, Kershaw O, Schreiber J, Guzmán CA, Bruder D*, Hernandez-Vargas EA*.
In vivo Neutralization of Pro-inflammatory Cytokines During Secondary Streptococcus pneumoniae Infection Post Influenza A Virus Infection.
Front Immunol. 2019 Aug 14;10:1864. doi: 10.3389/fimmu.2019.01864. eCollection  2019.*'contributed equally
 

Volckmar J, Knop L, Stegemann-Koniszewski S, Schulze K, Ebensen T, Guzmán CA, Bruder D.
The STING activator c-di-AMP exerts superior adjuvant properties than the formulation poly(I:C)/CpG after subcutaneous vaccination with soluble protein antigen or DEC-205-mediated antigen targeting to dendritic cells.
Vaccine.
2019 Aug 14;37(35):4963-4974. doi: 10.1016/j.vaccine.2019.07.019. Epub  2019 Jul 15.

Heyner M, Schreier S, Kröger A.
The brain-immune cells axis controls tissue specific immunopathology.
Cell Mol Immunol. 2019 Feb;16(2):101-103. doi: 10.1038/s41423-018-0176-y. Epub 2018 Nov 7.

Deigendesch Nr, Schlüter D, Siebrt E, Stenzel W.
Infections of the central nervous system by protozoa, helminths and fungi.
Nervenarzt. 2019 Jun;90(6):623-641. doi: 10.1007/s00115-019-0719-1.

Nishanth G, Schlüter D.
Blood-Brain Barrier in Cerebral Malaria: Pathogenesis and Therapeutic Intervention
Trends Parasitol. 2019 Jul;35(7):516-528. doi: 10.1016/j.pt.2019.04.010. Epub  2019 May 27.

Sanchez-Ruiz M, Brunn A, Montesinos-Rongen M, Rudroff C, Hartmann M, Schlüter D, Pfitzer G, Deckert M.
Enteric Murine Ganglionitis Induced by Autoimmune CD8 T Cells Mimics Human Gastrointestinal Dysmotility.
Am J Pathol. 2019 Mar;189(3):540-551. doi: 10.1016/j.ajpath.2018.11.016.

Wang X, Mulas F, Yi W, Brunn A, Nishanth G, Just S, Waisman A, Brück W, Deckert M, Schlüter D.
OTUB1 inhibits CNS autoimmunity by preventing IFN-γ-induced hyperactivation of astrocytes.
EMBO J.
2019 Apr 3. pii: e100947. doi: 10.15252/embj.2018100947.

Halbedel S, Prager R, Banerji S, Kleta S, Trost E, Nishanth G, Alles G, Hölzel C, Schlesiger F, Pietzka A, Schlüter D, Flieger A.
A Listeria monocytogenes ST2 clone lacking chitinase ChiB from an outbreak of non-invasive gastroenteritis.
Emerging Microbes & Infections, 8:1, 17-28, DOI:10.1080/22221751.2018.1558960.

2018

K. Vogel, M. Pierau, A. Arra, K. Lampe, D. Schlüter, C. Arens, M.C.. Brunner-Weinzierl.
Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus.
Sci Rep. 8:16904. doi:10.1038/s41598-018-35161-5.

Schultz K, Grieger Lindner C, Li Y, Urbánek P, Ruschel A, Minnich K, Bruder D, Gereke M, Sechi A, Herrlich P.
Gamma secretase dependent release of the CD44 cytoplasmic tail upregulates IFI16 in cd44-/- tumor cells, MEFs and macrophages.
PLoS One. 2018 Dec 12;13(12):e0207358. doi: 10.1371/journal.pone.0207358. eCollection  2018.

Heyner M, Schreier S, Kröger A.
The brain-immune cells axis controls tissue specific immunopathology.
Cell Mol Immunol.
2018 Nov 7. doi: 10.1038/s41423-018-0176-y. [Epub ahead of print]

Abdissa K, Nerlich A, Beineke A, Ruangkiattikul N, Pawar V, Heise U, Janze N, Falk C, Bruder D, Schleicher U, Bogdan C, Weiss S and Goethe R.
Presence of Infected Gr-1intCD11bhiCD11cint Monocytic Myeloid Derived Suppressor Cells Subverts T Cell Response and Is Associated With Impaired Dendritic Cell Function in Mycobacterium avium-Infected Mice. Front. Immunol. 2018, 9:2317. doi: 10.3389/fimmu.2018.02317

Bernal I, Hofmann JD, Bulitta B, Klawonn F, Michel A-M, Jahn D, Neumann-Schaal M, Bruder D* and Jänsch L*.
Clostridioides difficile Activates Human Mucosal-Associated Invariant T Cells.
Front. Microbiol. 2018, 9:2532. doi: 10.3389/fmicb.2018.02532. *equal contribution.

Liakopoulos V, Jeron A, Shah A, Bruder D,  Mertens PR , Gorny X.
Hemodialysis-related changes in phenotypical features of monocytes.
Scientific Reports (2018) 8:13964. DOI:10.1038/s41598-018-31889-2.

Soni D#, Wang DM#, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C.
Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury.
Cell Death Discov.
2018 May 16;4:60. doi: 10.1038/s41420-018-0056-3. eCollection  2018. # contributed equally

Meinshausen AK, Märtens N, Berth A, Färber J, Awiszus F, Macor P, Lohmann CH, Bertrand J.
The terminal complement pathway is activated in septic but not in aseptic shoulder revision arthroplasties.
J Shoulder Elbow Surg. 2018 Aug 20. pii: S1058-2746(18)30508-1. doi: 10.1016/j.jse.2018.06.037. [Epub ahead of print]

Jeron A, Boehme JD, Volckmar J, Gereke M, Yevsa T, Geffers R, Guzman CA, Schreiber J, Stegemann-Koniszewski S, Bruder D.
Respiratory Bordetella bronchiseptica Carriage is Associated with Broad Phenotypic Alterations of Peripheral CD4+CD25+ T Cells and Differentially Affects Immune Responses to Secondary Non-Infectious and Infectious Stimuli in Mice.
Int. J. Mol. Sci. 2018, 19(9), 2602; https://doi.org/10.3390/ijms19092602.

Kurhade C, Schreier S, Lee YP, Zegenhagen L, Hjertqvist M, Dobler G, Kröger A, Överby AK.
Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice.
Emerg Infect Dis. 2018 Sep;24(9):1709-1712. doi: 10.3201/eid2409.171825.

Probst-Kepper M, Geginat G.
Neue Antibiotika für die Therapie von multiresistenten gramnegativen Bakterien.
Anästhesiol Intensivmed Notfallmed Schmerzther. 2018. 53:529-542.

Mertens A, Barche D, Scheinpflug L, Scholz FG, Vielhaber S, Scherlach C, Tröger U, Geginat G, Färber J, Arens C. 
Rhinocerebral Mucormycosis.
Laryngorhinootologie. 2018 May 16. doi: 10.1055/a-0619-5143. [Epub ahead of print] German. PMID: 29768642

Veluswamy P, Bruder D.
PD-1/PD-L1 pathway inhibition to restore effector functions in exhausted CD8+ T cells: chances, limitations and potential risks.
Transl Cancer Res 2018;7(Suppl 4):S530-S537. doi: 10.21037/tcr.2018.04.04

Bulitta B, Zuschratter W, Bernal I, Bruder D, Klawonn F, von Bergen M, Garritsen HSP, Jänsch L.
Proteomic definition of human mucosal-associated invariant T cells determines their unique molecular effector phenotype.
Eur J Immunol. 2018 May 11. doi: 10.1002/eji.201747398. [Epub ahead of print]

Stegemann-Koniszewski S, Behrens S, Boehme JD, Hochnadel I, Riese P, Guzmán CA, Kröger A, Schreiber J, Gunzer M, Bruder D.
Respiratory Influenza A Virus Infection Triggers Local and Systemic Natural Killer Cell Activation via Toll-Like Receptor 7.
Front Immunol. 2018 Feb 13;9:245. doi: 10.3389/fimmu.2018.00245.

2017

Geginat G, Probst-Kepper, M. 
Neue Antibiotika gegen multiresistente Bakterien. 
Der Mikrobiologe. 2017. 27 (4), 177-183

Schlüter D, Heidel FH.
Macrophage's little helper: vitamin A directs alternatively activated monocyte-derived macrophages to tissue-resident macrophages.
Cell Mol Immunol. 2017 Oct;14(10):805-808. doi: 10.1038/cmi.2017.58. Epub  2017 Jul 10.

Swierzy IJ, Händel U, Kaever A, Jarek M, Scharfe M, Schlüter D, Lüder CGK.
Divergent co-transcriptomes of different host cells infected with Toxoplasma gondii reveal cell type-specific host-parasite interactions.
Sci Rep. 2017 Aug 3;7(1):7229. doi: 10.1038/s41598-017-07838-w.

Lim MCC, Maubach G, Sokolova O, Feige MH, Diezko R, Buchbinder J, Backert S, Schlüter D, Lavrik IN, Naumann M.
Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-κB and caspase-8-dependent apoptotic cell death.
Cell Death Differ. 2017 Sep;24(9):1621-1631. doi: 10.1038/cdd.2017.89. Epub  2017 Jun 2.


Eyer L, Kondo H, Zouharova D, Hirano M, Valdés JJ, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Kröger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, De Clercq E, Yoshii K, Ruzek D.
Escape of tick-borne flavivirus from 2' -C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness.
J Virol. 2017 Aug 16. pii: JVI.01028-17. doi: 10.1128/JVI.01028-17. [Epub ahead of print]

Frede A, Neuhaus B, Knuschke T, Wadwa M, Kollenda S, Klopfleisch R, Hansen W, Buer J, Bruder D, Epple M, Westendorf AM.
Local delivery of siRNA-loaded calcium phosphate nanoparticles abates pulmonary inflammation.
Nanomedicine. 2017 Aug 8. pii: S1549-9634(17)30148-X. [Epub ahead of print]

Kröger A.
IRFs as competing pioneers in T-cell differentiation.
Cell Mol Immunol. 2017 Aug;14(8):649-651. doi: 10.1038/cmi.2017.37. Epub  2017 Jun 19.

Schuster M, Plaza-Sirvent C, Matthies AM, Heise U, Jeron A, Bruder D, Visekruna A, Hühn J, Schmitz I.
c-REL and IkBNS govern common and independent steps of regulatory T-cell development from novel CD122-expressing pre-precursors.
J Immunol. 2017 Aug 1;199(3):920-930. doi: 10.4049/jimmunol.1600877. Epub  2017 Jun 26.

Boehme J, Stegemann-Koniszewski S, Wissing J, Autengruber A, Jänsch L, Jeron A, Bruder D.
Chronic lung inflammation primes humoral immunity and augments anti-pneumococcal resistance.
Sci Rep. in press              

Boehme JD and Bruder D.
IL-33: jack-of-all-trades in the orchestration of respiratory antibacterial immunity.
Cell Mol Immunol. 2017 Jul 10. doi: 10.1038/cmi.2017.53. [Epub ahead of print]

Link A, Langner C, Schirrmeister W, Habendorf W, Weigt J, Venerito M, Tammer I, Schlüter D, Schlaermann P, Meyer TF, Wex T, Malfertheiner P.
Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA.
World J Gastroenterol. 2017 July 14; 23(26): 4712-4723.

Schalk E, Biehl LM, Färber J, Schlüter D, Vehreschild MJGT, Fischer T.
Determination of a cut-off time-point for prophylactic exchange of central venous catheters for prevention of central venous catheters-related bloodstream infections in patients with hematological malignancies
Infect Control Hosp Epidemiol. 2017 Jul;38(7):888-889. doi: 10.1017/ice.2017.92. Epub  2017 May 18.

Färber J, Illiger S, Berger F, Gärtner B, von Müller L, Lohmann CH, Bauer K, Grabau C, Zibolka S, Schlüter D, Geginat G.
Management of a cluster of Clostridium difficile infections among patients with osteoarticular infections.
Antimicrob Resist Infect Control. 2017 Feb 15;6:22. doi: 10.1186/s13756-017-0181-4.

Volckmar J, Gereke M, Ebensen T, Riese P, Philipsen L, Lienenklaus S, Wohlleber D, Klopfleisch R, Stegemann-Koniszewski S, Müller AJ, Gruber AD, Knolle P, Guzman CA, Bruder D.
Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.
Sci Rep 2017; DOI: 10.1038/srep43985

Sakthivel P, Breithaupt A, Gereke M, Copland DA, Schulz C, Gruber AD, Dick AD, Schreiber J, Bruder D.
Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients: Potential Implication of the CD200/CD200R Axis in the Disease Course.
Lung. 2017 Feb;195(1):59-68. doi: 10.1007/s00408-016-9962-4.

Nishanth G, Wolleschak D, Fahldieck C, Fischer T, Mullally A, Perner F, Schnöder TM, Just S, Heidel FH, Schlüter D.
Gain of function in Jak2V617F positive T-cells.
Leukemia. 2017 Apr;31(4):1000-1003. doi: 10.1038/leu.2017.6. Epub 2017 Jan 11.

Schmid U, Stenzel W, Koschel J, Raptaki M, Wang X, Naumann M, Matuschewski K, Schlüter D, Nishanth G.
CYLD Dampens CD8+ T cell Responses and is a Critical Factor for Experimental Cerebral Malaria and Blood-Brain Barrier Damage.
Front Immunol., 8:27.doi: 10.3389/fimmu.2017.00027.

Mracsko E, Stegemann-Koniszewski S, Na SY, Dalpke A, Bruder D, Lasitschka F, Veltkamp R.
A Mouse Model of Post-Stroke Pneumonia Induced by Intra-Tracheal Inoculation with Streptococcus pneumoniae.
Cerebrovasc Dis. 2017;43(3-4):99-109. doi: 10.1159/000452136. Epub  2017 Jan 4.

Sakthivel P, Bruder D.
Mechanism of granuloma formation in sarcoidosis.
Curr Opin Hematol. 2017 Jan;24(1):59-65.

Parzmair GP, Gereke M, Haberkorn O, Annemann M, Podlasly L, Kliche S, Reinhold A, Schraven B, Bruder D.
ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens.
J Leukoc Biol. 2017 Feb;101(2):407-419. doi: 10.1189/jlb.1A0216-090RR. Epub  2016 Sep 7.

2016

Just S, Nishanth G, Buchbinder JH, Wang X, Naumann M, Lavrik I, Schlüter D.
A20 Curtails Primary but Augments Secondary CD8+ T Cell Responses in Intracellular Bacterial Infection.
Sci Rep. 2016 Dec 22;6:39796. doi: 10.1038/srep39796.

Asghar N, Lee YP, Nilsson E, Lindqvist R, Melik W, Kröger A, Överby AK, Johansson M.
The role of the poly(A) tract in the replication and virulence of tick-borne encephalitis virus.
Sci Rep. 2016 Dec 16;6:39265. doi: 10.1038/srep39265.

Duvigneau S, Sharma-Chawla N, Boianelli A, Stegemann-Koniszewski S, Nguyen VK, Bruder D, Hernandez-Vargas EA.
Hierarchical effects of pro-inflammatory cytokines on the post-influenza susceptibility to pneumococcal coinfection.
Sci Rep.
2016 Nov 22;6:37045. doi: 10.1038/srep37045.

Ahmed SA, Hofmüller W, Seibold M, de Hoog GS, Harak H, Tammer I, van Diepeningen AD, Behrens-Baumann W.
Tintelnotia, a new genus in Phaeosphaeriaceae harbouring agents of cornea and nail infections in humans.
Mycoses.
2016 Dec 1. doi: 10.1111/myc.12588. [Epub ahead of print]

Zegenhagen L, Kurhade C, Kröger A, Overby AK.
Differences in IPS-1-Mediated Innate Immune Responses between Neurotrophic Flavivirus Infection.
J Neuroinfect Dis. 2016 7(1).

Pieler MM*, Frentzel S*, Bruder D,  Wolff MW, Reichl U.
A cell culture-derived whole virus influenza A vaccine based on magnetic sulfated cellulose particles confers protection in mice against lethal influenza A virus infection.
Vaccine.
2016 Dec 7;34(50):6367-6374. doi: 10.1016/j.vaccine.2016.10.041. *contributed equally.

Sakthivel P, Breithaupt A, Gereke M, Copland DA, Schulz C, Gruber AD, Dick AD, Schreiber J, Bruder D.
Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients: Potential Implication of the CD200/CD200R Axis in the Disease Course.
Lung. 2016 Nov 18. [Epub ahead of print]

Lindqvist R, Mundt F, Gilthorpe JD, Wölfel S, Gekara NO, Kröger A, Överby AK.
Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects.
J Neuroinflammation. 2016 Oct 24;13(1):277.

Sharma-Chawla N, Sender V, Kershaw O, Gruber AD, Volckmar J, Henriques-Normark B, Stegemann-Koniszewski S, Bruder D.
Influenza A virus infection predisposes hosts to secondary infection with different Streptococcus pneumoniae serotypes with similar outcome but serotype-specific manifestation.
Infect. Immun. Accepted manuscript posted online 19 September 2016 , doi:10.1128/IAI.00422-16

Hrdinka M, Sudan K, Just S, Schlüter D, Reinhold D, Jordan BA, Ginschel P, Schraven B, Kreutz MR.
Normal development and function of T cells in proline rich 7 (Prr7) deficient mice.
PLoS One. 2016 Sep 22;11(9):e0162863. doi: 10.1371/journal.pone.0162863. eCollection 2016.

Kummer A, Nishanth G, Koschel J, Klawonn F, Schlüter D, Jänsch L.
Listeriosis down-regulates hepatic cytochrome P450 enzymes in sub-lethal murine infection.
Proteomics Clin Appl. 2016 Oct;10(9-10):1025-1035. doi: 10.1002/prca.201600030.

Boianelli A, Sharma-Chawla N, Bruder D, Hernandez-Vargas EA.
Oseltamivir PK/PD modelling and simulation to evaluate treatment strategies against Influenza-Pneumococcus coinfection.
Front. Cell. Infect.Microbiol. doi: 10.3389/fcimb.2016.00060

Andzinski L, Spanier J, Kasnitz N, Kröger A, Jin L, Brinkmann MM, Kalinke U, Weiss S, Jablonska J, Lienenklaus S.
Growing tumors induce a local STING dependent type I IFN response in dendritic cells.
Int J Cancer. 2016 Sep 15;139(6):1350-7. doi: 10.1002/ijc.30159.

Sakthivel P, Sharma N, Klahn P, Gereke M, Bruder D.
Abscisic acid: a phytohormone and mammalian cytokine as novel pharmacon with potential for future development into clinical applications.
Curr Med Chem. 2016;23(15):1549-70.


Stegemann-Koniszewski S, Jeron A, Gereke M, Geffers R, Kröger A, Gunzer M, Bruder D.
Alveolar type II epithelial cells contribute to the anti-influenza A virus response in the lung by integrating pathogen- and microenvironment-derived signals.
mBio 7(3):e00276-16. doi:10.1128/mBio.00276-16.

Möhle L, Mattei D, Heimesaat MM, Bereswill S, Fischer A, Alutis M, French T, Hambardzumyan D, Matzinger P,  Dunay IR #, Wolf SA #   (# equally contributed last authors)
Ly6Chi monocytes provide a link between antibiotic-induced changes in gut microbiota and adult hippocampal neurogenesis.
Cell Rep. 2016 May 31;15(9):1945-56. doi: 10.1016/j.celrep.2016.04.074.

Zegenhagen L, Kurhade C, Koniszewski N, Överby AK, Kröger A.
Brain heterogeneity leads to differential innate immune responses and modulates pathogenesis of viral infections.
Cytokine Growth Factor Rev.
2016 Aug;30:95-101. doi: 10.1016/j.cytogfr.2016.03.006.

Kaase M, Schimanski S, Schiller R, Beyreiß B, Thürmer A, Steinmann J, Kempf VA, Hess C, Sobottka I, Fenner I, Ziesing S, Burckhardt I, von Müller L, Hamprecht A, Tammer I, Wantia N, Becker K, Holzmann T, Furitsch M, Volmer G, Gatermann SG.
Multicentre investigation of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in German hospitals.
Int J Med Microbiol.
2016 Sep;306(6):415-20. doi: 10.1016/j.ijmm.2016.05.009.


Wex K, Schmid U, Just S, Wang X, Wurm R, Naumann M, Schlüter D, Nishanth G.
Receptor-Interacting Protein Kinase-2 Inhibition by CYLD Impairs Antibacterial Immune Responses in Macrophages.
Front Immunol. 2016 Jan 19;6:650. doi: 10.3389/fimmu.2015.00650. eCollection 2015.

Castiglia V, Piersigilli A, Ebner F, Janos M, Goldmann O, Damböck U, Kröger A, Weiss S, Knapp S, Jamieson AM, Kirschning C, Kalinke U, Strobl B, Müller M, Stoiber D, Lienenklaus S, Kovarik P.
Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue.
Cell Host Microbe. 2016 Mar 9;19(3):375-87. doi: 10.1016/j.chom.2016.02.003.

Nocera DA, Roselli E, Araya P, Nuñez NG, Lienenklaus S, Jablonska J, Weiss S, Gatti G, Brinkmann MM, Kröger A, Morón G, Maccioni M.
In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration.
J Immunol. 2016 Mar 15;196(6):2860-9. doi: 10.4049/jimmunol.1501044.

Möhle L, Israel N, Paarman K, Krohn M, Pietkiewicz S, Müller M, Lavrik I, Buguliskis J, Schott B, Schlüter D, Gundelfinger E, Montag D, Seifert U, Pahnke J, Dunay IR.
Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.
Acta Neuropathol Commun., 2016 Mar 16;4(1):25. doi: 10.1186/s40478-016-0293-8.

Kurhade C, Zegenhagen L, Weber E, Nair S, Michaelsen-Preusse K, Spanier J, O Gekara N, Kröger A#, Överby AK#.
Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.
J Neuroinflammation. 2016 13:22 doi: 10.1186/s12974-016-0487-9 #:contributed equally

Rolle AM, Hasenberg M, Thornton CR, Solouk-Saran D, Männ L, Weski J, Maurer A, Fischer E, Spycher PR, Schibli R, Boschetti F, Stegemann-Koniszewski S, Bruder D, Severin GW, Autenrieth SE, Krappmann S, Davies G, Pichler BJ, Gunzer M, Wiehr S.
ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo.
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1026-33. doi: 10.1073/pnas.1518836113.

Walch-Rückheim B, Kiefer R, Geginat G, Schmitt MJ, Breinig F.
Coexpression of human perforin improves yeast-mediated delivery of DNA and mRNA to mammalian antigen-presenting cells.
Gene Ther (2016) 23, 103–107; doi:10.1038/gt.2015.77

Andzinski L, Kasnitz N, Stahnke S, Wu CF, Gereke M, von Köckritz-Blickwede M, Schilling B, Brandau S, Weiss S, Jablonska J.
Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human. I
nt J Cancer. 2016 Apr 15;138(8):1982-93. doi: 10.1002/ijc.29945.

 

2015

Sakthivel P, Grunewald J, Eklund A, Bruder D*, Wahlström J*.
Pulmonary sarcoidosis is associated with high-level ICOS expression on lung regulatory T cells - possible implications for the ICOS/ICOS-L axis in disease course and Resolution.
Clin Exp Immunol. 2016 Feb;183(2):294-306. doi: 10.1111/cei.12715. Epub  2015 Nov 24. *Senior authors contributed equally.

Krause J, Geginat G, Tammer I.
Prostaglandin E2 from Candida albicans Stimulates the Growth of Staphylococcus aureus in Mixed Biofilms.
PLoS One
. 2015 Aug 11;10(8):e0135404. doi: 10.1371/journal.pone.0135404. eCollection 2015.

Stokkou S, Geginat G, Schlüter D, Tammer I.
Direct disk diffusion test using European Clinical Antimicrobial Susceptibility Testing breakpoints provides reliable results compared with the standard method.
Eur J Microbiol Immunol (Bp). 2015 Mar;5(1):103-11. doi: 10.1556/EUJMI-D-15-00005. Epub 2015 Mar 26.

Tammer I, Geginat G, Lange S, Kropf S, Lodes U, Schlüter D, Lippert H, Meyer F.
Antibiotic Consumption and the Development of Antibiotic Resistance in Surgical Units.
Zentralbl Chir. 2015, DOI: 10.1055/s-0033-1351087

Schalk E, Färber J, Fischer T, Heidel FH.
Central Venous Catheter-Related Bloodstream Infections in Obese Hematologic Patients.
Infect Control Hosp Epidemiol. 2015 Aug;36(8):995-6. doi: 10.1017/ice.2015.107. Epub 2015 May 20.

Schalk E, Hanus L, Färber J, Fischer T, Heidel FH.
Prediction of central venous catheter-related bloodstream infections (CRBSIs) in patients with haematologic malignancies using a modified Infection Probability Score (mIPS).
Ann Hematol. 2015 Sep;94(9):1451-6. doi: 10.1007/s00277-015-2387-y. Epub 2015 May 3.

Fu T, Znalesniak EB, Kalinski T, Möhle L, Biswas A, Salm F, Dunay IR*, Hoffmann W*.
TFF Peptides Play a Role in the Immune Response Following Oral Infection of Mice with Toxoplasma Gondii.
Eur J Microbiol Immunol (Bp). 2015 Sep 18;5(3):221-31. doi: 10.1556/1886.2015.00028. 2015 Sep. PMID: 26495133; *contributed equally

Montagna GN, Biswas A, Hildner K, Matuschewski K, Dunay IR. Batf3 deficiency proves the pivotal role of CD8α+ dendritic cells in protection induced by vaccination with attenuated Plasmodium sporozoites.
Parasite Immunol. 2015 Aug 18. doi: 10.1111/pim.12222.

Arroyo-Olarte RD, Brouwers JF, Kuchipudi A, Helms JB, Biswas A, Dunay IR, Lucius R, Gupta N.
Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence.
PLoS Biol. 2015 Nov 13;13(11):e1002288. doi: 10.1371/journal.pbio.1002288. eCollection 2015.

Dankowski T, Buck D, Andlauer TF, Antony G, Bayas A, Bechmann L, Berthele A, Bettecken T, Chan A, Franke A, Gold R, Graetz C, Haas J, Hecker M, Herms S, Infante-Duarte C, Jöckel KH, Kieseier BC, Knier B, Knop M, Kümpfel T, Lichtner P, Lieb W, Lill CM, Limmroth V, Linker RA, Loleit V, Meuth SG, Moebus S, Müller-Myhsok B, Nischwitz S, Nöthen MM, Paul F, Pütz M, Ruck T, Salmen A, Stangel M, Stellmann JP, Strauch K, Stürner KH, Tackenberg B, Then Bergh F, Tumani H, Waldenberger M, Weber F, Wiendl H, Wildemann B, Zettl UK, Ziemann U, Zipp F, Hemmer B, Ziegler A; German Competence Network for Multiple Sclerosis (KKNMS).
Successful Replication of GWAS Hits for Multiple Sclerosis in 10,000 Germans Using the Exome Array.
Genet Epidemiol. 2015 Oct 26. doi: 10.1002/gepi.21933. [Epub ahead of print]

Boianelli A, Nguyen VK, Ebensen T, Schulze K, Wilk E, Sharma N, Stegemann-Koniszewski S, Bruder D, Toapanta FR, Guzmán CA, Meyer-Hermann M,  Hernandez-Vargas EA.
Modeling Influenza Virus - A roadmap for influenza Research.
Viruses. 2015 Oct 12;7(10):5274-304. doi: 10.3390/v7102875.

Jannasch O, Kelch B, Adolf D, Tammer I, Lodes U, Weiss G, Lippert H, Mroczkowski P.
Nosocomial Infections and Microbiologic Spectrum after Major Elective Surgery of the Pancreas, Liver, Stomach, and Esophagus.
Surg Infect (Larchmt).2015 Jun;16(3):338-45. doi: 10.1089/sur.2013.248.


Boehme JD, Pietkiewicz S, Lavrik I, Jeron A, Bruder D.
Morphological and Functional Alterations of Alveolar Macrophages in a Murine Model of Chronic Inflammatory Lung Disease.
Lung. 2015 Aug 30. doi: 10.1007/s00408-015-9797-4  [Epub ahead of print]

Schumak B, Klocke K, Kuepper JM, Biswas A, Dije-Maletz A, Limmer A, van Rooijen N, Mack M, Hoerauf A, Dunay IR.
Specific depletion of Ly6C hi inflammatory monocytes prevents immunopathology in experimental cerebral malaria.
PLoS One. 2015 Apr 17;10(4):e0124080. doi: 10.1371/journal.pone.0124080. eCollection 2015.

Tschernig T*, Hartwig C*, Jeron A*, Thai Dinh Q, Gereke M, Bruder D.
First genomic analysis of dendritic cells from lung and draining lymph nodes in murine asthma.
Int J Genomics. 2015;2015:638032. doi: 10.1155/2015/638032. Epub 2015 Feb 24. *first authors contributed equally. 

Wurm R, Just S, Wang X, Wex K, Schmid U, Blanchard N, Waisman A, Schild HJ, Naumann M, Schlüter D, Nishanth G.
Protective dendritic cell responses against listeriosis induced by the short form of the deubiquitinating enzyme CYLD are inhibited by full-length CYLD.
Eur J Immunol. 2015 May 45(5):1366-76. doi: 10.1002/eji.201445116.

Biswas A, Bruder D, Wolf SA, Jeron A, Mack M, Heimesaat MM, Dunay IR.
Ly6Chi monocytes control cerebral toxoplasmosis.
J Immunol. 2015 Apr 1;194(7):3223-35. doi: 10.4049/jimmunol.1402037.

Blanchard N, Dunay IR*, Schlüter D*.   
Persistence of Toxoplasma gondii in the central nervous system: a fine tuned balance between the parasite, the brain and the immune system.
Parasite Immunol. 2015 Mar;37(3):150-8. doi: 10.1111/pim.12173. * contributed equally

Dong W, Wang H, Shahzad K, Bock F, Al-Dabet M, Ranjan S, Wolter J, Kohli S, Hoffmann J, Dhople VM, Zhu C, Lindquist JA, Esmon CT, Gröne E, Gröne HJ, Madhusudhan T, Mertens PR, Schlüter D*, Isermann B*.
Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protei 1 Ubiquitination.
J Am Soc Nephrol. 2015 Nov;26(11):2789-99. doi: 10.1681/ASN.2014080846. Epub  2015 May 26. (* gleichrangige Autorenschaft) 

Detje C, Lienenklaus S, Chhatbar C, Spanier J, Prajeeth C, Soldner C, Tovey M, Schlüter D, Weiss S, Stangel M, Kalinke U.
Upon intranasal VSV infection astrocytes in the olfactory bulb are important IFN-β producers that protect from lethal encephalitis.
J Virol. 2015 Mar 1; 89(5):2731-8. doi: 10.1128/JVI.02044-14.

Parlog A, Schlüter D, Dunay IR.
Toxoplasma gondii induced neuronal alterations.
Parasite Immunol. 2015 Mar;37(3):159-70. doi: 10.1111/pim.12157.

Stoycheva D, Deiser K, Stärck L, Nishanth G, Schlüter D, Uckert W, Schüler T.
Interferon-gamma regulates CD8+ memory  T cell differentiation and survival in response to  weak but not strong TCR signals.
J Immunol. 2015 194:553-9.doi:10.4049/jimmunol.1402058

Xuan NT*, Wang X*, Nishanth G, Waisman A, Borucki K, Isermann B, Naumann M, Deckert M, Schlüter D.
A20 expression in dendritic cells protects mice from LPS-induced mortality.
Eur J Immunol. 2015; doi: 10.1002/eji.201444795. *These authors contributed equally to this work.

Yeruva S, Chodisetti G, Luo M, Chen M, Cinar A, Ludolph L, Lünnemann M, Goldstein J, Singh AK, Riederer B, Bachmann O, Bleich A, Gereke M, Bruder D, Hagen S, He P, Yun C, Seidler U.
Evidence for a causal link between adaptor protein PDZK1 downregulation and Na+/H + exchanger NHE3 dysfunction in human and murine colitis.
Pflugers Arch. 2015 Aug;467(8):1795-807. doi: 10.1007/s00424-014-1608-x. Epub 2014 Oct 2.

2014

Tammer I, Geginat G, Lange S, Kropf S, Lodes U, Schlüter D, Lippert H, Meyer F.
Antibiotic Consumption and the Development of Antibiotic Resistance in Surgical Units.
Zentralbl Chir. 2016 Feb;141(1):53-61. doi: 10.1055/s-0033-1351087. Epub  2014 Apr 28.

Cholley P, Ka R, Guyeux C, Thouverez M, Guessennd N, Ghebremedhin B, Frank T, Bertrand X, Hocquet D.
Population structure of clinical Pseudomonas aeruginosa from West and Central African countries.
PLoS One. 2014 Sep 4;9(9):e107008. doi: 10.1371.

Schalk E, Färber J, Fischer T.
Multidrug-resistant gram-negative bacteria in hematology and oncology.
Infect Control Hosp Epidemiol. 2014 Sep;35(9):1203-4. doi: 10.1086/677646.

Stokkou S, Tammer I, Zibolka S, Grabau C, Geginat G.
Impact of minimal inhibitory concentration breakpoints on local cumulative bacterial susceptibility data and antibiotic consumption.
BMC Res Notes. 2014 Sep 3;7:603. doi: 10.1186/1756-0500-7-603.

Heimesaat MM*, Dunay IR*, Schulze S, Fischer A, Grundmann U, Alutis M, Kühl AA, Tamas A, Toth G, Dunay MP, Göbel UB, Reglodi D, Bereswill S.
Pituitary adenylate cyclase-activating polypeptide ameliorates experimental acute ileitis and extra-intestinal sequelae.
PLoS One. 2014 Sep 19;9(9):e108389. doi: 10.1371/journal.pone.0108389. *First authors contributed equally to this work.

Pleyer U, Schlüter D, Mänz M.
Ocular Toxoplasmosis: Recent Aspects of Pathophysiology and Clinical Implications.
Ophthalmic Res. 2014 Sep 19;52(3):116-123.

Petzold C, Steinbronn N, Gereke M, Strasser RH, Sparwasser T, Bruder D, Geffers R, Schallenberg S, Kretschmer K.
Fluorochrome-based definition of naturally occurring Foxp3+ regulatory T cells of intra- and extrathymic origin.
Eur J Immunol. 2014 Aug 26. doi: 10.1002/eji.201444750.

Heimesaat MM*, Dunay IR*, Alutis M, Fischer A, Möhle L, Göbel UB, Kühl AA, Bereswill S.
Nucleotide-Oligomerization-Domain-2 Affects Commensal Gut Microbiota Composition and Intracerebral Immunopathology in Acute Toxoplasma gondii Induced Murine Ileitis.
PLoS One. 2014 Aug 20;9(8):e105120. doi: 10.1371/journal.pone.0105120.*First authors contributed equally to the study.

Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, Moriera C, Price RN, Mårtensson A, Rosenthal PJ, Dorsey G, Sutherland CJ, Guérin P, Davis TM, Ménard D, Adam I, Ademowo G, Arze C, Baliraine FN, Berens-Riha N, Björkman A, Borrmann S, Checchi F, Dhorda MD, Djimdé AA, El-Sayed BB, Eshetu T, Eyase F, Falade C, Faucher JF, Fröberg G, Grivoyannis A, Hamour S, Houzé S, Johnson J, Kamugisha E, Kariuki S, Kiechel JR, Kironde F, LeBras PE, Malmberg M, Mwai L, Ngasala B, Nosten F, Nsobya SL, Oguike AN, Otienoburu SD, Ogutu B, Ouédraogo JB, Piola P, Rombo L, Schramm B, Somé AF, Thwing J, Ursing J, Wong RP, Zeynudin A, Zongo I, Plowe CV, Sibley CH.
Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors that Affect Treatment Outcomes for P. falciparum Malaria after Artemether-Lumefantrine and Artesunate-Amodiaquine.
Am J Trop Med Hyg. 2014 Jul 21. pii: 14-0031.

Schlüter D, Däubener W, Schares G, Groß U, Pleyer U, Lüder C.
Animals are key to human toxoplasmosis.
Int J Med Microbiol. 2014 Sep 10. 304:917-29. doi: 10.1016/j.ijmm.2014.09.002

Sakthivel P, Gereke M, Breithaupt A, Fuchs D, Gigliotti L, Gruber AD, Dianzani U, Bruder D.
Attenuation of Immune-Mediated Influenza Pneumonia by Targeting the Inducible Co-Stimulator (ICOS) Molecule on T Cells.
PLoS One. 2014 Jul 16;9(7):e100970. doi: 10.1371/journal.pone.0100970  

Pick J, Arra A, Lingel H, Hegel JK, Huber M, Nishanth G, Jorch G, Fischer KD, Schlüter D, Tedford K, Brunner-Weinzierl MC.
CTLA-4 (CD152) enhances the Tc17 differentiation program.
Eur J Immunol. 2014 Apr 10. 44:2139-52. doi: 10.1002/eji.201343497.  

Tammer I, Reuner J, Hartig R, Geginat G.
Induction of Candida albicans biofilm formation on silver-coated vascular grafts.
J Antimicrob Chemother. 2014 May;69(5):1282-5. doi: 10.1093/jac/dkt521.

Schalk E, Tammer I, Heidel FH.
Germ and hematology: underlying disease influences diversity of germ spectra and antibiotic therapy.
Infect Control Hosp Epidemiol. 2014 Feb;35(2):208-10. doi: 10.1086/674864.

Möhle L, Parlog A, Pahnke J, Dunay IR.
Spinal cord pathology in chronic experimental Toxoplasma gondii infection.
Eur J Microbiol Immunol (Bp)
. 2014 Mar;4(1):65-75. doi: 10.1556/EuJMI.4.2014.1.6.

Bereswill S, Kühl AA, Alutis M, Fischer A, Möhle L, Struck D, Liesenfeld O, Göbel UB, Dunay IR, Heimesaat MM.
The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis.
Gut Pathog. 2014 Jun 6;6:19. doi: 10.1186/1757-4749-6-19. *Senior authors contributed equally to the study.

Klose CS, Flach M, Möhle L, Rogell L, Hoyler T, Ebert K, Fabiunke C, Pfeifer D, Sexl V, Fonseca-Pereira D, Domingues RG, Veiga-Fernandes H, Arnold SJ, Busslinger M, Dunay IR, Tanriver Y, Diefenbach  A.
Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages.
Cell 2014 Apr 10;157(2):340-356.

Selgrad M, Tammer I, Langner C, Bornschein J, Meißle J, Kandulski A, Varbanova M, Wex T, Schlüter D, Malfertheiner P.
Different antibiotic susceptibility between antrum and corpus of the stomach, a possible reason for treatment failure of Helicobacter pylori infection.
World J Gastroentero. 2014 Nov 21;20(43):16245-51. doi: 10.3748/wjg.v20.i43.16245.

Schalk E, Geginat G, Schulz C, Schlüter D, Fischer T.
The incidence of norovirus infections in cancer patients shows less seasonal variability compared to patients with other diseases.
Ann Hematol. 2014 May;93(5):889-90.

Nair S, Michaelsen-Preusse K, Finsterbusch K, Stegemann-Koniszewski S, Bruder D, Grashoff M, Korte M, Köster M, Kalinke U, Hauser J, Kröger A.
Interferon Regulatory Factor-1 Protects from Fatal Neurotropic Infection with Vesicular Stomatitis Virus by Specific Inhibition of Viral Replication in Neurons.
PLOS Pathog. 2014;10(3):DOI: 10.1371/journal.ppat.1003999 

Parlog A, Harsan LA, Zagrebelsky M, Weller M, von Elverfeldt D, Mawrin C, Korte M, Dunay IR.
Chronic murine toxoplasmosis is defined by subtle changes in the neuronal connectivity.
Dis Model Mech 2014;Apr 7(4):459-69. doi: 10.1242/dmm.014183.

Kominsky DJ, Campbell EL, Ehrentraut SF, Wilson KE, Kelly CJ, Glover LE, Collins CB, Bayless AJ, Saeedi B, Dobrinskikh E, Bowers BE, Macmanus CF, Müller W, Colgan SP, Bruder D.
IFN-γ-Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia.
J Immunol. 2013 Dec 23. doi: 104049/jimmunol.1301757

Maenz M, Schlüter D, Liesenfeld O, Schares G, Gross U, Pleyer U.
Ocular Toxoplasmosis Past, present and new aspects of an old disease.
Prog Retin Eye Res. 2014 39:77-106: doi: 10.1017/j.preteyeres.2013.12.005.

 

2013

Tammer I, Geginat G, Lange S, Kropf S, Lodes U, Schlüter D, Lippert H, Meyer F.
Antibiotikaverbrauch und Resistenzentwicklung in der Chirurgie/Antibiotic consumption and development of antibiotic resistance in surgical units.
Zentralbl Chir, accepted

Wang Xu, Deckert M, Xuan N T, Nishanth G, Just S, Waisman A, Nauman M, Schlüter D. Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-kB- and STAT1-dependent chemokine production in astrocytes.
Acta Neuropathol, 126(5): 711-724.

Telieps T, Ewald F, Gereke M, Annemann M, Rauter Y, Schuster M, Ueffing N, von Smolinski D, Gruber AD, Bruder D, Schmitz I.
Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection.
Eur J Immunol. 2013 Jun;43(6):1499-510. doi: 10.1002/eji.201242819. Epub 2013 May 2. 

Stegemann-Koniszewski S, Gereke M, Orrskog S, Lienenklaus S, Pasche B, Bader SR, Gruber AD, Akira S, Weiss S, Henriques-Normark B, Bruder D*, Gunzer M*. *equal contribution
TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection.
J Innate Immun. 2013;5(1):84-96. doi: 10.1159/000345112.
 
Jensen S, Steffensen MA, Holbech Jensen BA, Schlüter D, Christensen JP, Randrup Thomsen A.
Adenovirus-based vaccine against Listeria monocytogenes: Extending the concept of invariant chain linkage.
J Immunol, 2013 Oct 15;191(8):4152-64. doi: 10.4049/jimmunol.1301290.

Tegtmeyer N, Traverso FR, Rohde M, Oyarzabal OA, Lehn N, Schneider-Brachert W, Ferrero RL, Fox JG, Berg DE, Backert S.
Electron Microscopic, Genetic and Protein Expression Analyses of Helicobacter acinonychis Strains from a Bengal Tiger.
PLoS One. 2013;8(8):e71220. doi: 10.1371/journal.pone.0071220

Selgrad M, Meißle J, Bornschein J, Kandulski A, Langner C, Varbanova M, Wex T, Tammer I, Schlüter D, Malfertheiner P.
Antibiotic susceptibility of Helicobacter pylori in mid-Germany and its relationship to the number of eradication therapies.
Eur J Gastroenterol Hepatol, 2013 Nov;25(11):1257-60. doi: 10.1097/MEG.0b013e3283643491.

Nishanth G, Deckert M, Wex K, Massoumi R, Schweitzer K, Naumann M, Schlüter D.
CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production.
PLoS Pathog 9(6): e1003455. doi:10.1371/journal.ppat.1003455 

Milnik A, Gazis A, Tammer I, Bartels C.
Immunocompetent young man with cerebral abscess and cortical venous infarction mimicking cerebritis caused by Gemella morbillorum.
BMJ Case Rep. 2013 Jan 25;2013. doi: pii: bcr2012007252. 10.1136/bcr-2012-007252

S. Bereswill, A. Fischer, I. R. Dunay, A. A. Kühl, U. B. Göbel, O.Liesenfeld und M. M. Heimesaat
Pro-inflammatory potential of Escherichia coli strains K12 and Nissle 1917 in a murine model of acute ileitis.
Eur J Microbiol Immunol 2013/Jun, Doi: 10.1556/EuJMI.3.2013.2.6

 

2012

Jeron A, Hansen W, Ewert F, Buer J, Geffers R and Bruder D.
ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells.
BMC Genomics 2012, 13:705 doi:10.1186/1471-2164-13-705, published: 17 December 2012

Gereke M, Autengruber A, Gröbe L, Jeron A, Bruder D, Stegemann-Koniszewski S.
Flow cytometric isolation of primary murine type II alveolar epithelial cells for functional and molecular studies.
J Vis Exp. 2012 Dec 26;(70). doi:pii: 4322. 10.3791/4322.

Grauling-Halama S, Schenk S, Bubert A, Geginat G.
Linkage of Bacterial Protein Synthesis and Presentation of MHC Class I-Restricted Listeria monocytogenes-Derived Antigenic Peptides.
PLoS One. 2012; 7(3): e33335. 

Geginat G, Kaiser D, Schrempf S.
Evaluation of third-generation ELISA and a rapid immunochromatographic assay for the detection of norovirus infection in fecal samples from inpatients of a German tertiary care hospital.
Eur J Clin Microbiol Infect Dis. 2012 May;31(5):733-7. Epub 2011 Aug 2.

Stegemann-Koniszewski S, Gereke M, Orrskog S, Lienenklaus S, Pasche B, Bader SR, Gruber AD, Akira A, Weiss S, Henriques-Normark B, Bruder D*, Gunzer M*.
TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection.
Innate Immun. 2013;5(1):84-96. doi: 10.1159/000345112. Epub 2012 Nov 15.*Both senior authors contributed equally to the study.

Albrecht M, Arnhold M, Lingner S, Mahapatra S, Bruder D, Hansen G, Dittrich AM.
IL-4 attenuates pulmonary epithelial cell-mediated suppression of T cell priming.
PLoS One. 2012;7(9):e45916. doi: 10.1371/journal.pone.0045916.

Wang X, Haroon F, Karray S, Deckert M, Schlüter D.
Astrocytic Fas ligand-expression is required to induce T-cell apoptosis and recovery from experimental autoimmune encephalomyelitis.
Eur J Immunol. 2013 Jan;43(1):115-24. doi: 10.1002/eji.201242679. Epub 2012 Nov 21.

Händel U, Brunn A, Drögemüller K, Müller W, Deckert M, Schlüter D.
Neuronal gp130 expression is crucial to prevent neuronal loss, hyperinflammation, and lethal course of murine Toxoplasma encephalitis.
Am J Pathol. 2012 Jul;181(1):163-73. Epub 2012 May 26.

Tosiek MJ, BaderS, GruberAD, BuerJ, Gereke M, Bruder D.
CD8+ T cells responding to alveolar antigen lack CD25 expression and fail to precipitate autoimmunity. 
Am J Respir Cell Mol Biol.2011-0387OCFirst published online September 13, 2012 as doi:10.1165/rcmb.2011-0387OC.

Karlmark KR, Tacke F, Dunay IR.
Monocytes in health and disease.
Eur J Microbiol Immunol.2012.June;2:97-102

Autengruber A, Gereke M, Hansen G, Hennig C, Bruder D.
Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.
Eur J Microbiol Immunol.2012;2:112-120.
 

Haroon F, Händel U, Angenstein F, Goldschmidt J, Kreutzmann P, Lison H, Fischer KD, Scheich H, Wetzel W, Schlüter D, Budinger E.
Toxoplasma gondii Actively Inhibits Neuronal Function in Chronically Infected Mice.
PLoS One. 2012;7(4):e35516. Epub 2012 Apr 18.

Weichert S, Reinshagen K, Zahn K, Geginat G, Dietz A, Kilian AK, Schroten H, Tenenbaum T.
Candidiasis caused by Candida kefyr in a neonate: Case report.
BMC Infect Dis. 2012 Mar 18;12:61.
 

Schneider H, Geginat G, Hogardt M, Kramer A, Dürken M, Schroten H, Tenenbaum T.
Pseudomonas aeruginosa Outbreak in a Pediatric Oncology Care Unit Caused by an Errant Water Jet into Contaminated Siphons.
Pediatr Infect Dis J. 2012 Jun;31(6):648-50

Kupfahl C, Tsikas D, Niemann J, Geginat G, Hof H.
Production of prostaglandins, isoprostanes and thromboxane by Aspergillus fumigatus: identification by gas chromatography-tandem mass spectrometry and quantification by enzyme immunoassay.
Mol Immunol. 2012 Jan;49(4):621-7. Epub 2011 Nov 25.

Aibinu I, Odugbemi T, König W, Ghebremedhin B.
Sequence Type ST131 and ST10 Complex (ST617) predominant among CTX-M-15-producing Escherichia coli isolates from Nigeria.
Clin Microbiol Infect. 2012 Mar;18(3):E49-51. doi: 10.1111/j.1469-0691.2011.03730.x. Epub 2011 Dec 22.
 

Runsewe-Abiodun IT, Efunsile M, Ghebremedhin B, Sotimehin AS, Ajewole J, Akinleye J, König B, König W.
Malaria diagnostics: a comparative study of blood microscopy, a rapid diagnostic test and polymerase chain reaction in the diagnosis of malaria.
J Trop Pediatr. 2012 Apr;58(2):163-4. Epub 2011 Jun 23.

Sakthivel P, Gereke M, Bruder D.
Therapeutic intervention in cancer and chronic viral infections: Antibody mediated manipulation of PD-1/PD-L1 interaction.
Rev Recent Clin Trials. 2012; 7:10-23. 
 
Kolesnik M, Bonnekoh B, Tammer I, Gollnick H, Sauerbrei A.
Varicella outbreak in an Indian couple living in Germany caused by VZV clade VI acquired during a trip to the Netherlands.
Case Rep Med. 2012;2012:838241. Epub 2012 Mar 14.
 
Ghebremedhin B.
Bacterial infections in the elderly patient: Focus on sitafloxacin.
Clinical medicine insights:Libertas Academical Clinical medicine insights, Therapeutics, Bd.4.2012,185-200.
 
Ghebremedhin B.
Extended-Spectrum-Betalaktamasen (ESBL): gestern ESBL - heute ESBL, Carbapenemase-Bildner und multiresistente Bakterien.
DMW. Stuttgart: Thieme, Bd. 137.2012, 50, 2657-2662.
 
Ghebremedhin B, König W.
Comparative study of nasal bacterial carriage in pediatric patients from two different geographical regions.
Eur J Microbiol Immunol.2012, 3, 205-209.
 
Behrens-Baumann W, Seibold M, Hofmüller W, Walter S, Haeberle H, Wecke T, Tammer I, Tintelnot K.
Benefit of polyhexamethylene biguanide in Fusarium keratitis.
Ophthalmic Res. Basel: Karger, Bd.48.2012, 4, 171-176.
 

2011

Boehm M, Krause-Gruszczynska M, Rohde M, Tegtmeyer N, Takahashi S, Oyarzabal OA, Backert S.
Major host factors involved in epithelial cell invasion of Campylobacter jejuni: Role of fibronectin, integrin beta1, FAK, Tiam-1 and DOCK180 in activating Rho GTPase Rac1.
Front Cell Infect Microbiol. 2011 Dec;1:1-13.
 
Heimesaat MM, Dunay IR, Fuchs D, Trautmann D, Fischer A., Kühl AA, Loddenkemper C, Siegmund B, Batra A, Bereswill S, Liesenfeld O.
The distinct roles of MMP-2 and MMP-9 in acute DSS colitis.
Eur J Microbiol Immunol. 2011 Dec;4:302-310.
 

Heimesaat MM, Dunay IR, Fuchs D, Trautmann D, Fischer A, Kühl AA, Loddenkemper C, Batra A, Siegmund B, Krell HW, Bereswill S, Liesenfeld O.
Selective gelatinase blockage ameliorates acute DSS colitis.
Eur J Microbiol Immunol. 2011 Sept;3:228-236.

Alberts R, Chen H, Pommerenke C, Smit AB, Spijker S, Williams RW, Geffers R, Bruder D*, and Schughart, K*. *both senior authors contributed equally
Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for autoimmune disease.
BMC Genomics 2011, 12:610 doi:10.1186/1471-2164-12-610 

Ghebremedhin B, König B, König W.
BD GeneOhm-MRSA Assay for Detection of Methicillin-Resistant Staphylococcus Aureus Directly in Nasal and Non-Nasal Swab Specimens from Haematologic Patients.
Eur J Microbiol Immunol. 2011;4:297-301.
 

Weiss G, Tammer I, Wolff S.
Resistenzentwicklung in der operativen Intensivtherapie.
Zentralbl Chir.2011;136(2):143-51.

Tammer I, Geginat G, Schlüter D.
Perioperative Prophylaxe und Therapie von Infektionen - Perioperative Antibiotikaprophylaxe
Anästhesiol Intensivmed Notfallmed Schmerther. 2011;46:674-681.

Geginat G, Kaiser D, SchrempfS.
Evaluation of 3rd generation ELISA and a rapid immunochromatographic assay for the detection of norovirus infection in fecal samples from inpatients of a German tertiary care hospital.
Eur J Clin Microbiol Infect Dis.2011;DOI 10.1007/s10096-011-1366-z

Bazan DB, Geginat G, Breinit T, Schmitt MJ, Breinig F.
Uptake of various yeast genera by antigen-presenting cells and influence of subcellular antigen localization on the activation of ovalbumin-specific CD8 T lymphocytes.
Vaccine. 2011 Oct 19;29(45):8165-73.

Tegtmeyer N, Wittelsberger R, Hartig R, Wessler S, Martinez-Quiles N, Backert S.
Serine Phosphorylation of Cortactin Controls Focal Adhesion Kinase Activity and Cell Scattering Induced by Helicobacter pylori.
Cell Host Microbe.2011;9(6):520-31.

Tegtmeyer N, Wessler S, Backert S.
Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis.
FEBS J.2011;278(8):1190-202

Tegtmeyer N, Backert S.
Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the Helicobacter pylori CagA protein.
Eur J Cell Biol. 2011;90(11):880-90. Epub 2011 Jan 17.

Aibinu IE, Pfeifer Y, Ogunsola F, Odugbemi T, König W, Ghebremedhin B.
Emergence of β-lactamases OXA-10, VEB-1 and CMY in Providencia spp. from Nigeria.
J Antimicrob Chemother. 2011;66(8):1931-2.

Ghebremedhin B.
Pharmacotherapy of invasive fungal infections with Voriconazole.
Clin Med Rev Ther. 2011; 3: 1-13.

Efunshile M, Runsewe-Abiodun T, König W, König B, Ghebremedhin B.
Prevalence of the molecular marker of Chloroquine resistance (PFCRT76) in Nigeria five years after the withdrawal of the drug as first line antimalarial: Cross sectional study.
S Afr J Child Health 2011;5(2):39-42.

Runsewe-Abiodun T, Efunsile M, Ghebremedhin B,  Sotimehin AS, Ajewole J, Akinleye J, König B, König W.
Malaria Diagnostics: A comparative study of Blood Microscopy, a Rapid Diagnostic Test and Polymerase Chain Reaction (PCR) in the diagnosis of malaria.
J Tropic. Ped. 2011;Epub ahead of print

Pachathundikandi SK, Brandt S, Madassery J, Backert S.
Induction of TLR-2 and TLR-5 Expression by Helicobacter pylori Switches cagPAI-Dependent Signalling Leading to the Secretion of IL-8 and TNF-a.
PLoS One. 2011 May 9;6(5):e19614.

Haroon F, Drögemüller K, Händel U, Brunn A, Reinhold D, Nishanth G, Mueller W, Trautwein C, Ernst M, Deckert, M, Schlüter D.
Gp130-Dependent Astrocytic Survival Is Critical for the Control of Autoimmune Centrol Nervous System Inflammation.
J Immunol. 2011 Jun 1;186(11):6521-31.

Tammer I, Tintelnot K, Braun-Dullaeus RC, Mawrin C, Scherlach C, Schlüter D, König W.
Infections due to Pseudallescheria/Scedosporium species in patients with advanced HIV disease - a diagnostic and therapeutic challenge.
Int J Infect Dis. 2011 Jun;15(6):e422-9.

Hövelmeyer N, Reissig S, Nguyen TX, Adams-Quack P, Lukas D, Nikolaev A, Schlüter D, Waisman A.
A20 deficiency B cell enhances B-cell proliferation and results in the development auf autoantibodies.
Eur J Immunol. 2011 Mar;41(3):595-601.

2010

Backert S, Kenny B, Gerhard R, Tegtmeyer N, Brandt S.
PKA-mediated phosphorylation of EPEC-Tir at serine residues 434 and 463 - A novel pathway in regulating Rac1 GTPase function.
Gut Microbes.2010;1:94-99.

Hoy, B., Löwer, M., Weydig, C., Carra, G., Tegtmeyer, N., Geppert, T., Plattner, P., Sewald, N., Backert, S., Schneider, G., Wessler, S.
Helicobacter pylori HtrA is a novel secreted virulence factor which cleaves E-Cadherin to disrupt intercellular adhesion. 
EMBO Rep.2010;Oct.11(10):798-804.

Rivas Traverso, F., Bohr, U.R.M., Oyarzabal, O.A., Rohde, M., Clarici, A., Wex, T., Kuester, D., Malfertheiner, P., Fox, J.G., Backert, S.
Morphological, genetic and biochemical characterization of Helicobacter magdeburgensis, a novel species isolated from the intestine of laboratory mice.
Helicobacter.2010;15: 403-415.

Backert, S., Tegtmeyer, N.
The Versatility of the Helicobacter pylori Vacuolating Cytotoxin VacA in Signal Transduction and Molecular Crosstalk.
Toxins.2010;2: 69-92.

Stradal. T.E.B., Backert, S.
Wie EHEC das Aktinzytoskelett der Wirtszelle beeinflussen.
Biospektrum.2010;16: 624-627.

Backert, S., Naumann, M.
What a disorder: pro-inflammatory signaling during Helicobacter pylori infections.
Trends Microbiol.2010;Nov.18(11)479-86.

Onyango DM, Kakai R, Nyandago WE, Ghebremedhin B, König W, König B.
Integron-plasmid mediated antibiotic resistance and virulence factors in clinical Salmonella enterica serovars in rural Western Kenya.
Afr J Pharm Pharmacol.2010;4(7):490-497.

Körner H, McMorran B, Schlüter D, Fromm P.
The role of tumour necrosis factor in parasitic diseases: Still more questions than answers.
Int J Parasitol.2010;40(8):879-88.

Saha A, Backert S, Hammond CE, Gooz M, Smolka AJ
Helicobacter pylori CagL activates ADAM17 to in duce repression of the gastric H, K-ATPase alpha subunit.
Gastroenterology.2010;139(1):239-48.

Tegtmeyer N, Hartig R, Delahay RM, Rohde M, Brandt S, Conradi J, Takahashi S, Smolka AJ, Sewald N, Backert S.
A small Fibronectin-mimicking protein from bacterial induces cell spreading and focal adhesion formation.
J Biol Chem.2010;285(30):23515-26.

Olofsson A, Vallström A, Petzold K, Tegtmeyer N, Schleucher J, Carlsson S, Haas R, Backert S, Wai SN, Gröbner G, Arnqvist A.
Biochemical and functional characterization of Helicobacter pylori vesicles.
Mol Microbiol. 2010 Sep;77(6):1539-55.

Backert S, Tegtmeyer N, Selbach M.
The versatility of Helicobacter pylori CagA effector protein functions: The master key hypothesis.
Helicobacter.2010;15(3):163-76.

Brunn A, Utermöhlen O, Sánchez Ruiz M, Montesinos-Rongen M., Blau T, Schlüter D, Deckert M.
Dual role of B cells with accelerated onset but reduced disease activity in P0106-125-induced experimental autoimmune neuritis of IgH0/0 mice.
Acta Neuropathol. 2010 Nov;120(5):667-81.

Nishanth G, Sakowicz-Burkiewicz M, Händel U, Kliche S, Wang X, Naumann M, Deckert M, Schlüter D.
Protective Toxoplasma gondii-specific T cell responses require the T cell-specific expression of protein kinase C-1.
Infect Immun.2010;24:78(8):3454-3464.

Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Núñez G, Schlüter D, Flavell RA, Sutterwala FS, Sher A.
Cutting Edge: Caspase-1 Independent IL-1b Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo.
J Immunol.2010;184:3326-3330.

Schalk E, Bohr UR, König B, Scheinpflug K, Mohren M.
Clostridium difficile-associated diarrhoea, a frequent complication in patients with acute myeloid leukaemia.
Ann Hematol.2010;89(1):9-14.

Tautenhahn J, Meyer F, Bürger T, Schmidt U, Lippert H, König W, König B.  
Interactions of neutrophils with silver-coated vascular polyester grafts. In: Langenbecks`s archives of surgery.
Berlin: Springer.2010; Bd.395,2, 143-149.

2009

Deckert M, Schlüter D.
Comment on "Critical roles of NK and CD8+ T cells in Central Nervous System Listeriosis".
J Immunol. 2009 May 15;182(10):6360-8.

Speegle L, Miller ME, Backert S, Oyarzabal OA.
Use of cellulose filters to isolate Campylobacter spp. from naturally contaminated retail broiler meat.
J Food Prot. 2009 Dec;72(12):2592-6.

Tegtmeyer N, Backert S.
Bacterial type III effectors inhibit cell lifting by targeting integrin-linked kinase.
Cell Host Microbe. 2009 Jun 18;5(6):514-6.

Sason H, Milgrom M, Weiss AM, Melamed-Book N, Balla T, Grinstein S, Backert S, Rosenshine I, Aroeti B.
Enteropathogenic Escherichia coli subverts phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate upon epithelial cell infection.
Mol Biol Cell. 2009 Jan;20(1):544-55.

Onyango MD, Ghebremedhin B, Waindi EN, Kakai R, Rabsch W, Tietze E, König W, König B.
Phenotypic and genotypic analysis of clinical isolates Salmonella serovar Thyphimurium in western Kenya.
J Infect Dev Ctries. 2009; 3(9):685-694.

Ghebremedhin B, Olugbosi MO, Raji AD, Layer F, Bakare RA, König B, König W.
Emergence of a community-associated methicillin-resistant Staphylococcus aureus strain with a unique resistance profile in Southwest Nigeria.
J Clin Microbiol. 2009 Sept;47(9):2975-2980.

Ghebremedhin B, Bluemel A, Neumann KH, König B, König W.
Peritonitis due to Neosartorya pseudofischeri in an elderly patient undergoing peritoneal dialysis successfully treated with voriconazole: Case-report and review of the literature.
J Med Microbiol. 2009; 58:678-682.

Ghebremedhin B, Engelmann I, König W, König B.
Comparison of the performance of the rapid antigen detection actimInfluenza A&B test and RT-PCR in different respiratory specimens.
J Med Microbiol. 2009 Mar; 58(Pt 3):365-70.

Brandt S, Wessler S, Hartig R, Backert S.
Helicobacter pylori activates protein kinase C delta to control Raf in MAP kinase signalling: role in AGS epithelial cell scattering and elongation.
Cell Motil Cytoskeleton 2009; 66(10):874-92.

Svensson H, Hansson M, Kilhamn J, Backert S, Quiding-Järbrink M.
Selective Upregulation of Endothelial E-Selectin in Response to Helicobacter pylori-Induced Gastritis.
Infect Immun 2009; 77(7):3109-16.

Brandt S, Kenny B, Rohde M, Martinze-Quiles N, Backert S.
Dual infection system identifies a crucial role for PKA-mediated serin phosphorylation of the EPEC-Tir injected effector protein in regulating Rac1 function.
Cell Microbiol 2009; 11(8):1254-1271.

Selbach M, Paul FE, Brandt S, Guye P, Daumke O, Backert S.
Host Cell Interactome of Tyrosine-Phosphorylated Bacterial Proteins.
Cell Host Microbe 2009; 5:397-403.

Tegtmeyer N, Zabler D, Schmidt D, Hartig R, Brandt S, Backert S.
Importance of EGF receptor, HER2/neu and Erk1/2 kinase signaling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonisitic effects of the vacuolating cytotoxin VacA.
Cell Microbiol. 2009 Mar;11(3):488-505

Mroczkowski P, Lauf H, Lippert H, König W, Meyer F.
Erregerspektrum chirurgischer Infektionen im 10-Jahres-Vergleich 1995-2004 eines mikrobiologischen Routinemonitorings.
Zentralbl Chir. 2009 Jun;134(3):226-30

Lodes U, Meyer F, König B, Lippert H.
Mikrobiologisches Sepsis-Screening chirurgischer Intensivpatienten mit dem "Lightcycler" Septifast®-Test - eine Pilotstudie.
Zentralbl Chir. 2009 Jun;134(3):249-53

Buchkapitel


Tammer I, Clarici A, Thies F, König B, König W.
Nonfermenter: Pseudomonas spp. und verwandte Spezies.
In "Burkhardt, Mikrobiologische Diagnostik, 2. Auflage", edited by Neumeister et al.
Thieme-Verlag Stuttgart 2009, Kapitel 21 (21.11), 476-493.

2008


Färber J, Moder KA, Layer F, Tammer I, König W, König B.
Extended-Spectrum Beta-Lactamase Detection with Different Panels for Automated Susceptibility Testing and with a Chromogenic Medium.
J Clin Microbiol 2008.46(11):3721-3727.

Ghebremedhin B, Layer F, König W, König B.
Genetic classification and distinguishing of Staphylococcus species based on different partial gene sequences: gap, 16S-rRNA, hsp65, sodA, rpoB, and tuf gene.
J Clin Microbiol 2008. 46(3):1019-1025.

Bonnekoh B, Falk K, Reckling KF, Kenklies S, Nitsche A, Ghebremedhin B, Pokrywka A, Franke I, Thriene B, König W, Pauli G, Gollnick H.
Cowpox infection transmitted from a domestic cat.
JDDG 2008. 6(3):210-3.

Hänel I, Alter T, Backert S.
Tagungsbericht 25. Jenaer Symposium: Campylobacter-Infektionen.
Bundesgesundheitsbl -Gesundheitsforsch - Gesundheitsschutz 2008;51(11):1347-1352

Wessler S, Backert S.
Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori.
Trends Microbiol. 2008 Aug;16(8):397-405.

Drögemüller K, Helmuth U, Brunn A, Sakowicz-Burkiewicz M, Gutmann DH, Mueller W, Deckert M, Schlüter D.
Astrocyte gp130-expression is critical for the control of Toxoplasma encephalitits.
J Immunol. 2008 Aug 15;181(4):2683-93.

Backert S, Feller SM, Wessler S.
Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.
Trends Biochem Sci. 2008 Feb;33(2):80-90.

Stenzel W, Soltek S, Sanchez-Ruiz M, Courts C, Akira S, Miletic H, Schlüter D, Deckert M.
Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess.
Am J Pathol 2008.172(1):132-45.

Sanchez-Ruiz M, Wilden L, Müller W, Stenzel W, Miletic H, Schlüter D, Deckert M.
Molecular mimicry between neurons and an intracerebral pathogen induces a CD8 T cell-mediated autoimmune disease.
J. Immunol. 2008.180:8421-8433.

Brunn A, Utermöhlen O, Carstow M, Sanchez-Ruiz M, Miletic H, Schlüter D, Deckert M.
CD4 T Cells mediate Axonal Damage and Spinal Cord Motor Neuron Apoptosis in Murine P0106-125-induced Experimental Autoimmune Neuritis.
Am. J. Pathol. 2008.173:93-105.

Sakowicz-Burkiewicz M, Helmuth U, Drögemüller K, Busch DH, Naumann M, Deckert M, Schlüter D.
Protein kinase C-q critically regulates the activation and proliferation of pathogen-specific T cells in murine listeriosis.
J Immunol 2008.180:5601-5612.

Torres J, Backert S.
Pathogenesis of Helicobacter pylori infection.
Helicobacter 2008. 13 (Suppl. 1): 13-17

Oyarzabal OA, Backert S, Williams LL, Lastovica AJ, Miller RS, Pierce SJ, Vieira SL, Rebollo-Carrato F.
Molecular typing, serotyping and cytotoxicity testing of Campylobacter jejuni strains isolated from commercial broilers in Puerto Rico.
J Appl Microbiol 2008 Sep;105(3):800-12.

Backert S, Selbach M.
Role of type IV secretion in Helicobacter pylori pathogenesis.
Cell Microbiol 2008. (Bd. 10)8:1573-1581.

Knauer O, Binai NA, Carra G, Beckhaus T, Hanschmann KM, Renné T, Backert S, Karas M, Wessler S.
Differential phosphoproteome profiling reveals a functional role for VASP in Helicobacter pylori-induced cytoskeleton turnover in gastric epithelial cells.
Cell Microbiol 2008. (Bd. 10)11:2285-2296

Tautenhahn J, Lobmann R, König B, Halloul Z, Lippert H, Bürger T.
The influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration.
Vasc Health Risk Manag. 2008;4(3):683-9.

Backert S, Fronzes R, Waksman G.
VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems?
Trends Microbiol 2008.16(9):409-13.

Buchkapitel


Arnold R, König W.
The role of proteinase-activated receptor (PAR)-mediated inflammation in RSV infection - modulation by peroxisome proliferator-activated receptor-g (PPARg) agonists in RSV infection.
In "Advances in Research & Management of Asthma and COPD - Proceedings of the World Asthma and COPD Forum", April 26-29, 2008 Dubai, UAE
Medimond International Proceedings 2008. 51-54.

2007


Krause-Gryszczynska M, van Alphen LB, Oyarzabal OA, Alter T, Hänel I, Schliephake A, König W, van Putten JPM, Konkel ME, Backert S.
Expression Patterns and Role of CadF in Campylobacter jejuni and Campylobacter coli.
FEMS Microbiology Letters 2007. 274:9-16

Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, König W, Backert S.
Helicobacter exploits integrin for type IV secretion and kinase activation.
Nature 2007.449(7164):862-866.

Moder KA, Layer F, König W, König B.
Rapid screening of clarithromycin resistance in Helicobacter pylori by pyrosequencing.
J Med Microbiol. 2007. 56(Pt 10):1370-6.

Layer F, Ghebremedhin B, König W, König B.
Differentiation of Staphylococcus spp. by Terminal-Restriction Fragment Length Polymorphism Analysis of Glyceraldehyd-3-Phosphate Dehydrogenase-Encoding Gene.
J Microbiol Methods. 2007. 70(3):542-9.

Arnold R, König W.
PPARg- and Toll-Like Receptor-2 Agonists might have Therapeutical Value in Respiratory Syncytial Virus (RSV) Induced Airway Disease: PPARg Agonists May Act in a PPARg-Independent Manner.
Allergy Clin Immunol Int: J World Allergy Org, Supplement 2 (2007):1-3.

Krause M, Rohde M, Hartig R, Genth H, Schmidt G, Keo T, König W, Miller WG, Konkel M, Backert S.
Role of the small Rho GTPases Rac1 and Cdc42 in host cell invasion of Campylobacter jejuni.
Cell Microbiol 2007. 9(10), 2431-2444.

Brandt S, Shafikhani S, Balachandran P, Jin S, Hartig R, König W, Engel J, Backert S.
Use of a novel co-infection system reveals a role for Rac, Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytskeletal rearrangements.
FEMS Immunol Med Microbiol., 2007; 50:190-205

Tammer I, Brandt S, Hartig A, König W, Backert S.
Activation of c-Abl kinase by Helicobacter pylori: a novel kinase of the CagA protein and mediator of host cell scattering.
Gastroenterology 2007, 132(4):1309-1319

Thies FL, König W, König B.
Rapid characterization of the normal and disturbed vaginal microbiata by application of 16S rRNA gene terminal RFLP fingerprinting.
JMM 2007, 56, 755-761

Arnold R, Neumann M, König W.
PPARg activators inhibit RSV-induced expression of ICAM-1 in human lung epithelial cells.
Immunology 2007,121: 71-81

Gilad J, Schwartz D, Layer F, Ghebremedhin B, Moder KA, König W, König B.
Identification of Staphylococcus Species with VITEK 2 System: the Case of Staphylococcus hominis.
J Clin Microbiol. 2007 45(2):685-6.

Ghebremedhin B, König W, Witte W, Hardy KJ, Hawkey PM, König B.
Subtyping of the ST22-MRSA-IV (Barnim epidemic MRSA strain) at an University Clinic in Germany from 2002-2005.
J Med Microbiol. 2007 Mar;56(Pt 3):365-75.

Tammer I, Seibold M, Krause H, Tintelnot K, König W, König B
Successful Topical Therapy with Voriconazole - A Case Report on a Pseudallescheriosis after Injury.
J Trauma 2007. May 62(5):1295-7.

Potturi-Venkata LP, Backert S, Vieira SL, Oyarzabal OA.
Evaluation of logistic processing to reduce cross-contamination of commercial broiler carcasses with Campylobacter spp.
J Food Prot. 2007 Nov;70(11):2549-54.

Moese S, Selbach M, Brinkmann V, Karlas A, Haimovich B, Backert S, Meyer TF.
The Helicobacter pyloris CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin.
Cell Microbiol 2007. 9:1148-1161.

Potturi-Venkata LP, Backert S, Lastovica AJ, Vieira SL, Norton RA, Miller RS, Pierce S, Oyarzabal OA.
Evaluation of different plate media for direct cultivation of campylobacter species from live broilers.
Poult Sci 2007, 86 (7): 1304-11

Oyarzabal OA, Backert S, Nagaraj M, Miller RS, Hussain SK, Oyarzabal EA.
Efficacy of supplemented buffered peptone water for the isolation of Campylobacter jejuni and C. coli from broiler retail products.
J Microbiol Methods 2007, 69(1): 129-36.

Oyarzabal OA, Rad R, Backert S.
Conjugative transfer of chromosomally encoded antibiotic resistance from Helicobacter pylori to Campylobacter jejuni.
J Clin Microbiol 2007, 45(2): 402-8.

Blumenthal B, Hoffmann C, Aktories K, Backert S, Schmidt G.
The cytotoxic necrotizing factors from Yersinia pseudotuberculosis and from Escherichia coli bind to different cellular receptors but take the same route to the cytosol.
Infect Immun 2007, 75(7):3344-3353

Backert S, Fischer W.
Transport von Proteinen und DNA: Typ IV-Sekretion bei Gram-negativen Bakterien.
Naturwiss. Rundschau 2007; 60(1): 10-17

Deckert M, Virna S, Sakowicz-Burkiewicz M, Lütjen S, Soltek S, Bluethmann H, Schlüter D.
The interleukin-1 receptor type 1 is essential for control of cerebral, but not systemic listeriosis.
Am J Pathol. 2007; 170:990-1002.

Mueller AK, Deckert M, Heiss K, Goetz K, Matuschewski K, Schlüter D.
Genetically attenuated Plasmodium berghei liver stages persits and elicit sterile protection primarily via CD8 T cells.
Am J Pathol, 171(1): 107-115

Schmidt JK, König B, Reichl U.
Characterization of a Three Bacteria Mixed Culture in a Chemostat: Evaluation and Application of a Quantitative Terminal-Restriction Fragment Polymorphism (T-RFLP) Analysis for Absolute and Species Cell Enumeration.
Biotechnol Bioeng 2007, MAR1; 96(4): 738-56

Kalinski T, Jentsch-Ullrich K, Fill S, König B, Costa SD, Roessner A.
Lethal candida sepsis associated with myeloperoxidase deficiency and pre-eclampsia.
APMIS 2007; 115:875-80

Müller AK, Heiss K, Goetz K, Matuschewski K, Deckert M, Schlüter D.
Correspondence: Assessment of Antibody Protection against Malaria Sporozoites Must Be Done by Mosquito Injection of Sporozoites.
Am J Pathol 2007. 171(4)1405-1407.

Buchkapitel


Arnold R, König W.
PPARg- and Toll-Like Receptor-2 Agonists Might have Therapeutical Value in Respiratory Syncytial Virus (RSV)-Induced Airway Disease: PPARg Agonists May Act in a PPARg-Independent Manner.
edited by S. Holgate et. al, Hogrefe & Huber Publishers
Proceedings of the 26th Symposium of the Collegium Internationale Allergologicum, Diseases and Impaired Barrier Funtion: 345-347, 2007

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