Publikationen
2024
Boehme J. und Bruder D.
Interaktion von sekretorischem IgA mit Bakterien in der Nase.
BIOspektrum 2024. DOI 10.1007/s12268-024-2152-7.
Camp B, Jorde I, Sittel F, Pausder A, Jeron A, Bruder D, Schreiber J, Stegemann- Koniszewski S.
Comprehensive analysis of lung macrophages and dendritic cells in two murine models of allergic airway inflammation reveals model- and subset-specific accumulation and phenotypic alterations.
Front. Immunol. 2024. 15:1374670. doi: 10.3389/fimmu.2024.1374670
Brandt, S.; Bernhardt, A.; Häberer, S.; Wolters, K.; Gehringer, F.; Reichardt, C.; Krause, A.; Geffers, R.; Kahlfuß, S.; Jeron, A.; Bruder, D.; Lindquist, J.A.; Isermann, B.; Mertens, P.R. Comparative Analysis of Acute Kidney Injury Models and Related Fibrogenic Responses: Convergence on Methylation Patterns Regulated by Cold Shock Protein.
Cells 2024, 13, 367. https://doi.org/10.3390/ cells13050367
2023
Dogra T, Pelz L, Boehme JD, Kuechler J, Kershaw O, Marichal-Gallardo P, Baelkner M, Hein MD, Gruber AD, Benndorf D, Genzel Y, Bruder D, Kupke SY, Reichl U.
Generation of "OP7 chimera" defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice.
Sci Rep. 2023 Nov 28;13(1):20936. doi: 10.1038/s41598-023-47547-1. PMID: 38017026; PMCID: PMC10684881.
Boehme JD and Bruder D.
Koinfektion mit Influenza und Pneumokokken: Influenza bereitet Infektion mit Pneumokokken vor.
Dtsch Arztebl 2023; 120(40): [14]; DOI: 10.3238/PersPneumo.2023.10.06.02
Vogel K, Arra A, Lingel H, Bretschneider D, Prätsch F, Schanze D, Zenker M, Balk S, Bruder D, Geffers R, Hachenberg T, Arens C, Brunner-Weinzierl MC.
Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood.
Nat Commun. 2023 Sep 23;14(1):5943.
Brauns S, Marquardt I, Thon C, Frentzel S, Jakob J, Färber J, Philipsen L, Jänsch L, Link A, Bruder D.
Mucosal-associated invariant T (MAIT) cells from Clostridioides difficile-infected patients exhibit a distinct proinflammatory phenotype and enhanced cytotoxic activity.
Int Immunol. 2023 Aug 7:dxad032. doi: 10.1093/intimm/dxad032. Epub ahead of print. PMID: 37549964.
Stegemann-Koniszewski S*, Frentzel S*, Bruder D.
Good and bad outcomes of respiratory viral infections-influenza A virus trains sustained antitumor immunity of macrophages in the lung.
Cell Mol Immunol. 2023 Apr 17. doi: 10.1038/s41423-023-01015-y. *Gleichberechtigte Erstautorinnen.
Metzdorf K, Jacobsen H, Greweling-Pils MC, Hoffmann M, Lüddecke T, Miller F, Melcher L, Kempf AM, Nehlmeier I, Bruder D, Widera M, Ciesek S, Pöhlmann S, Čičin-Šain L. TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection.
Viruses. 2023; 15(2):271. https://doi.org/10.3390/v15020271
Jakob J, Kröger A, Klawonn F, Bruder D* and Jänsch L*.
Translatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigenpresenting monocytes.
Front. Immunol. 2023. 14:1091837. doi: 10.3389/fimmu.2023.1091837.*Gleichberechtigte Letztautorenschaft.
2022
Frentzel S, Jeron A, Pausder A, Kershaw O, Volckmar J, Schmitz I and Bruder D.
IkBNS-deficiency protects mice from fatal Listeria monocytogenes infection by blunting pro-inflammatory signature in Ly6Chigh monocytes and preventing exaggerated innate immune responses.
Front. Immunol. 13:1028789. doi: 10.3389/fimmu.2022.1028789
Abdi Sarabi M, Shiri A, Aghapour M, Reichardt C, Brandt S, Mertens PR, Medunjanin S, Bruder D, Braun-Dullaeus RC, Weinert S.
Normoxic HIF-1α Stabilization Caused by Local Inflammatory Factors and Its Consequences in Human Coronary Artery Endothelial Cells.
Cells 2022, 11, 3878. https://doi.org/10.3390/ cells11233878
Hernandez-Vargas EA, Velasco-Hernández JX, Bruder D.
Editorial: Multiscale computational approaches in infectious diseases.
Front Microbiol. 2022 Jul 29;13:947673. doi: 10.3389/fmicb.2022.947673. eCollection 2022.
Wenzek, C., Steinbach, P., Wirsdörfer, F., Sutter, K., Boehme, J.D., Geffers, R., Klopfleisch, R., Bruder, D., Jendrossek, V., Buer, J., Westendorf, A.M., Knuschke, T.
CD47 restricts antiviral function of alveolar macrophages during influenza virus infection.
ISCIENCE (2022), doi: https://doi.org/10.1016/j.isci.2022.105540
Jhutty SS*, Boehme JD*, Jeron A, Volckmar J, Schultz K, Schreiber J, Schughart K, Zhou K, Steinheimer J, Stöcker H, Stegemann-Koniszewski S, Bruder D**, Hernandez-Vargas EA**.
Predicting Influenza A Virus Infection in the Lung from Hematological Data with Machine Learning.
mSystems. 2022 Nov 8:e0045922. doi: 10.1128/msystems.00459-22. Online ahead of print.*gleichberechtigte Erstautorenschaft. **gleichberechtigte Letztautorenschaft.
Gelmez E, Lehr K, Kershaw O, Frentzel S, Vilchez-Vargas R, Bank U, Link A, Schüler T, Jeron A*, Bruder D*.
Characterization of Maladaptive Processes in Acute, Chronic and Remission Phases of Experimental Colitis in C57BL/6 Mice.
Biomedicines. 2022; 10(8):1903. https://doi.org/10.3390/biomedicines10081903. *gleichberechtigte Letztautorenschaft.
Cammann C, Israel N, Frentzel S, Jeron A, Topfstedt E, Schüler T, Simeoni L, Zenker M, Fehling HJ, Schraven B, Bruder D* and Seifert U*.
T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation.
Front. Immunol. 2022 13:958616. doi: 10.3389/fimmu.2022.958616. *gleichberechtigte Letztautorenschaft.
Pausder A**, Mras P**, Hoenicke L, Waldburg N, Lesker TR, Schreiber J, Strowig T, Boehme JD*, Bruder D.*
Altered nasal microbiota in asthmatic patients is not related to changes in secretory immunity in the nasopharynx.
Clin Exp Allergy. 2022 Jul 12. doi: 10.1111/cea.14200. Epub ahead of print. PMID: 35819876. **gleichberechtigte Erstautorenschaft; *gleichberechtigte Letztautorenschaft
Volckmar J, Melcher L, Bruder D.
Route, origin & valence matter: towards sophisticated next-generation vaccines to cope with the COVID-19 pandemic.
Signal Transduct Target Ther. 2022 Jun 15;7(1):188. doi: 10.1038/s41392-022-01053-4.
Aghapour M, Tulen CBM, Abdi Sarabi M, Weinert S, Müsken M, Relja B, van Schooten FJ, Jeron A, Braun-Dullaeus R, Remels AH, Bruder D.
Cigarette Smoke Extract Disturbs Mitochondria-Regulated Airway Epithelial Cell Responses to Pneumococci.
Cells. 2022 May 28;11(11):1771. doi: 10.3390/cells11111771. PMID: 35681466.
Aghapour M, Surender S and BruderD.
Beware the intruder: gasodermin A as molecular guardian preventing systemic dissemination of group A streptococci following local skin infection.
Cell Mol Immunol, 2022. https://doi.org/10.1038/s41423-022-00863-4
Aghapour M, Ubags ND, Bruder D, Hiemstra PS, Sidhaye V, Rezaee F, Heijink IH.
Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD.
Eur Respir Rev. 2022 Mar 23;31(163):210112. doi: 10.1183/16000617.0112-2021.
Hochnadel I, Hoenicke L, Petriv N, Neubert L, Reinhard E, Hirsch T, Alfonso JCL, Suo H, Longerich T, Geffers R, Lichtinghagen R, Guzmán CA, Wedemeyer H, Lenzen H, Manns MP, Bruder D, Yevsa T.
Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers.
Oncogene. 2022 Feb 16. doi: 10.1038/s41388-022-02222-z. Online ahead of print.
Pausder A, Fricke J, Schughart K, Schreiber J, Strowig T, Bruder D, Boehme JD.
Exogenous and Endogenous Triggers Differentially Stimulate Pigr Expression and Antibacterial Secretory Immunity in the Murine Respiratory Tract.
Lung. 2022 Feb;200(1):119-128. doi: 10.1007/s00408-021-00498-8. Epub 2021 Nov 26. PMID: 34825965; PMCID: PMC8881272.
Gelmez E, Jeron A, Bruder D.
Negative elongation factor: a key factor in the maintenance of intestinal epithelial barrier integrity.
Cell Mol Immunol. 2022 Jan 7. doi: 10.1038/s41423-021-00817-2.
Kim Y, Zheng X, Eschke K, Chaudhry MZ, Bertoglio F, Tomić A, Krmpotić A, Hoffmann M, Bar-On Y, Boehme J, Bruder D, Ebensen T, Brunotte L, Ludwig S, Messerle M, Guzman C, Mandelboim O, Hust M, Pöhlmann S, Jonjić S, Čičin-Šain L.
MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination.
Cell Mol Immunol. 2022 Jan 7:1-11. doi: 10.1038/s41423-021-00814-5.
2021
Marquardt I, Jakob J, Scheibel J, Hofmann JD, Klawonn F, Neumann-Schaal M, Gerhard R, Bruder D* and Jänsch L*.
Clostridioides difficile Toxin CDT Induces Cytotoxic Responses in Human Mucosal-Associated Invariant T (MAIT) Cells.
Front. Microbiol. 2021. 12:752549. doi: 10.3389/fmicb.2021.752549. *equal contribution
Exogenous and Endogenous Triggers Differentially Stimulate Pigr Expression and Antibacterial Secretory Immunity in the Murine Respiratory Tract.
Lung . 2021 Nov 26. doi: 10.1007/s00408-021-00498-8. Online ahead of print.
Düsedau HP, Steffen J, Figueiredo CA, Boehme JD, Schultz K, Erck C, Korte M, Faber-Zuschratter H, Smalla KH, Dieterich D, Kröger A, Bruder D, Dunay IR.
Influenza A Virus (H1N1) Infection Induces Microglial Activation and Temporal Dysbalance in Glutamatergic Synaptic Transmission.
mBio. 2021 Oct 26;12(5):e0177621. doi: 10.1128/mBio.01776-21.
Böning MAL, Parzmair GP, Jeron A, Düsedau HP, Kershaw O, Xu B, Relja B, Schlüter D, Dunay IR, Reinhold A, Schraven B, Bruder D.
Enhanced susceptibility of ADAP-deficient mice to Listeria monocytogenes infection is associated with an altered phagocyte phenotype and function.
Front. Immunol. published: 30 September 2021, doi: 10.3389/fimmu.2021.724855
Ruhnau J, Grote V, Juarez-Osorio M, Bruder D, Mahour R, Rapp E, Rexer TFT and Reichl U.
Cell-Free Glycoengineering of the Recombinant SARS-CoV-2 Spike Glycoprotein.
Front. Bioeng. Biotechnol. 2021. 9:699025. doi: 10.3389/fbioe.2021.699025
Elfaki Y, Yang J, Boehme J, Schultz K, Bruder D, Falk CS, Huehn J, Floess S.
Tbx21 and Foxp3 Are Epigenetically Stabilized in T-Bet+ Tregs That Transiently Accumulate in Influenza A Virus-Infected Lungs.
Int. J. Mol. Sci. 2021, 22, 7522. https:// doi.org/10.3390/ijms22147522
Rand U, Kupke SY, Shkarlet H, Hein MD, Hirsch T, Marichal-Gallardo P, Cicin-Sain L, Reichl U, Bruder D.
Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity.
Cells 2021, 10, 1756. https://doi.org/10.3390/cells10071756
Hoang QTM, Nguyen VK, Oberacher H, Fuchs D, Hernandez-Vargas EA, Borucki K, Waldburg N, Wippermann J, Schreiber J, Bruder D, Veluswamy P.
Serum Concentration of the Phytohormone Abscisic Acid Is Associated With Immune-Regulatory Mediators and Is a Potential Biomarker of Disease Severity in Chronic Obstructive Pulmonary Disease.
Front. Med. 8:676058. doi: 10.3389/fmed.2021.676058 (2021).
Volckmar J, Knop L, Hirsch T, Frentzel S, Erck C, van Ham M, Stegemann-Koniszewski S, Bruder D.
Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo.
J. Vis. Exp. (168), e62018, doi:10.3791/62018 (2021).
Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A.
Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.
Immunity. 2021 Mar 1:S1074-7613(21)00070-4. doi:10.1016/j.immuni.2021.02.004. Online ahead of print.
Elfaki Y, Robert PA, Binz C, Falk CS, Bruder D, Prinz I, Floess S, Meyer-Hermann M, Huehn J.
Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development in mice.
Eur J Immunol. 2021 Feb 26. doi: 10.1002/eji.202048981. Online ahead of print.
Luecke E, Jeron A, Kroeger A, Bruder D, Stegemann-Koniszewski S, Jechorek D, Borucki K, Reinhold D, Reinhold A, Foellner S, Walles T, Hachenberg T, Schreiber J.
Eosinophilic pulmonary vasculitis as a manifestation of the hyperinflammatory phase of COVID-19.
J Allergy Clin Immunol. 2021 Jan;147(1):112-113. doi: 10.1016/j.jaci.2020.09.026.
2020
Qingyu Wu Q, Jorde I, Kershaw O, Jeron A, Bruder D, Schreiber J, Stegemann-Koniszewski S.
Resolved Influenza A Virus Infection Has Extended Effects on Lung Homeostasis and Attenuates Allergic Airway Inflammation in a Mouse Model.
Microorganisms 2020, 8, 1878; doi:10.3390/microorganisms8121878.
Qingyu Wu Q, Jorde I, Kershaw O, Jeron A, Bruder D, Schreiber J, Stegemann-Koniszewski S.
Resolved Influenza A Virus Infection Has Extended Effects on Lung Homeostasis and Attenuates Allergic Airway Inflammation in a Mouse Model.
Microorganisms 2020, 8, 1878; doi:10.3390/microorganisms8121878.
Boehme JD, Frentzel S, Bruder D.
NMP4: a nuclear driver of innate inflammatory responses during influenza A virus infection.
Cell Mol Immunol (2020). https://doi.org/10.1038/s41423-020-0517-5
Bruder D.
Influenza – Prävalenz, Bedeutung und Implikationen für die Prävention und Gesundheitsförderung.
In: Tiemann M, Mohokum M (eds) Prävention und Gesundheitsförderung. Springer Reference Pflege – Therapie – Gesundheit. Springer, Berlin, Heidelberg (2020) https://doi.org/10.1007/978-3-662-55793-8_68-1
Sasaki K, Bruder D, Hernandez-Vargas E.
Topological data analysis to model the shape of immune responses during co-infections.
Commun Nonlinear Sci Numer Simulat 85 (2020) 105228. Epub ahead of print.
Böning MAL, Trittel S, Riese P, van Ham M, Heyner M, Voss M, Parzmair GP, Klawonn F, Jeron A, Guzman CA, Jänsch L, Schraven B, Reinhold A, Bruder D.
ADAP promotes degranulation and migration of NK cells primed during in vivo Listeria monocytogenes infection in mice.
Front Immunol. 2020 Jan 22; doi.org/10.3389/fimmu.2019.03144
Aghapour M, Remels AHV, Pouwels SD, Bruder D, Hiemstra PS, Cloonan SM, Heijink IH.
Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol.
2020 Jan 1;318(1):L149-L164. doi: 10.1152/ajplung.00329.2019. Epub 2019 Nov 6.
2019
Bruder, D. Dörries R.
Immunologie / Medizinische Mikrobiologie: 560 Abbildungen / herausgegeben von Herbert Hof, Dirk Schlüter; unter Mitarbeit von: Dunja Bruder, Oliver A. Cornely, Rüdiger Dörries, Gernot Geginat, Herbert Hof, Udo Reischl [und 3 anderen]
Stuttgart: Thieme, S. 75-164, 2019
Frentzel S, Katsoulis-Dimitriou K, Jeron A, Schmitz I, Bruder D.
Essential role of IκBNS for in vivo CD4+ T-cell activation, proliferation, and Th1-cell differentiation during Listeria monocytogenes infection in mice.
Eur J Immunol. 2019 Sep;49(9):1391-1398. doi: 10.1002/eji.201847961. Epub 2019 Jun 7
Zheng X, Oduro JD, Boehme JD, Borkner L, Ebensen T, Heise U, Gereke M, Pils MC, Krmpotic A, Guzmán CA, Bruder D, Čičin-Šain L.
Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge.
PLoS Pathog. 2019 Sep 16;15(9):e1008036.
Sharma-Chawla N, Stegemann-Koniszewski S, Christen H, Boehme JD, Kershaw O, Schreiber J, Guzmán CA, Bruder D*, Hernandez-Vargas EA*.
In vivo Neutralization of Pro-inflammatory Cytokines During Secondary Streptococcus pneumoniae Infection Post Influenza A Virus Infection.
Front Immunol. 2019 Aug 14;10:1864. doi: 10.3389/fimmu.2019.01864. eCollection 2019.*'contributed equally
Volckmar J, Knop L, Stegemann-Koniszewski S, Schulze K, Ebensen T, Guzmán CA, Bruder D.
The STING activator c-di-AMP exerts superior adjuvant properties than the formulation poly(I:C)/CpG after subcutaneous vaccination with soluble protein antigen or DEC-205-mediated antigen targeting to dendritic cells.
Vaccine. 2019 Aug 14;37(35):4963-4974. doi: 10.1016/j.vaccine.2019.07.019. Epub 2019 Jul 15.
2018
Schultz K, Grieger Lindner C, Li Y, Urbánek P, Ruschel A, Minnich K, Bruder D, Gereke M, Sechi A, Herrlich P.
Gamma secretase dependent release of the CD44 cytoplasmic tail upregulates IFI16 in cd44-/- tumor cells, MEFs and macrophages.
PLoS One. 2018 Dec 12;13(12):e0207358. doi: 10.1371/journal.pone.0207358. eCollection 2018.
Abdissa K, Nerlich A, Beineke A, Ruangkiattikul N, Pawar V, Heise U, Janze N, Falk C, Bruder D, Schleicher U, Bogdan C, Weiss S and Goethe R.
Presence of Infected Gr-1intCD11bhiCD11cint Monocytic Myeloid Derived Suppressor Cells Subverts T Cell Response and Is Associated With Impaired Dendritic Cell Function in Mycobacterium avium-Infected Mice.
Front. Immunol. 2018, 9:2317. doi: 10.3389/fimmu.2018.02317
Bernal I, Hofmann JD, Bulitta B, Klawonn F, Michel A-M, Jahn D, Neumann-Schaal M, Bruder D* and Jänsch L*.
Clostridioides difficile Activates Human Mucosal-Associated Invariant T Cells.
Front. Microbiol. 2018, 9:2532. doi: 10.3389/fmicb.2018.02532. *equal contribution.
Liakopoulos V, Jeron A, Shah A, Bruder D, Mertens PR , Gorny X.
Hemodialysis-related changes in phenotypical features of monocytes.
Scientific Reports (2018) 8:13964. DOI:10.1038/s41598-018-31889-2.
Jeron A, Boehme JD, Volckmar J, Gereke M, Yevsa T, Geffers R, Guzman CA, Schreiber J, Stegemann-Koniszewski S, Bruder D.
Respiratory Bordetella bronchiseptica Carriage is Associated with Broad Phenotypic Alterations of Peripheral CD4+CD25+ T Cells and Differentially Affects Immune Responses to Secondary Non-Infectious and Infectious Stimuli in Mice.
Int. J. Mol. Sci. 2018, 19(9), 2602; https://doi.org/10.3390/ijms19092602.
Veluswamy P, Bruder D.
PD-1/PD-L1 pathway inhibition to restore effector functions in exhausted CD8+ T cells: chances, limitations and potential risks.
Transl Cancer Res 2018;7(Suppl 4):S530-S537. doi: 10.21037/tcr.2018.04.04
Bulitta B, Zuschratter W, Bernal I, Bruder D, Klawonn F, von Bergen M, Garritsen HSP, Jänsch L.
Proteomic definition of human mucosal-associated invariant T cells determines their unique molecular effector phenotype.
Eur J Immunol. 2018 May 11. doi: 10.1002/eji.201747398. [Epub ahead of print]
Stegemann-Koniszewski S, Behrens S, Boehme JD, Hochnadel I, Riese P, Guzmán CA, Kröger A, Schreiber J, Gunzer M, Bruder D.
Respiratory Influenza A Virus Infection Triggers Local and Systemic Natural Killer Cell Activation via Toll-Like Receptor 7.
Front Immunol. 2018 Feb 13;9:245. doi: 10.3389/fimmu.2018.00245.
2017
Frede A, Neuhaus B, Knuschke T, Wadwa M, Kollenda S, Klopfleisch R, Hansen W, Buer J, Bruder D, Epple M, Westendorf AM.
Local delivery of siRNA-loaded calcium phosphate nanoparticles abates pulmonary inflammation.
Nanomedicine. 2017 Aug 8. pii: S1549-9634(17)30148-X. [Epub ahead of print]
Schuster M, Plaza-Sirvent C, Matthies AM, Heise U, Jeron A, Bruder D, Visekruna A, Hühn J, Schmitz I.
c-REL and IkBNS govern common and independent steps of regulatory T-cell development from novel CD122-expressing pre-precursors.
J Immunol. 2017 Aug 1;199(3):920-930. doi: 10.4049/jimmunol.1600877. Epub 2017 Jun 26.
Boehme J, Stegemann-Koniszewski S, Wissing J, Autengruber A, Jänsch L, Jeron A, Bruder D.
Chronic lung inflammation primes humoral immunity and augments anti-pneumococcal resistance.
Sci Rep. in press
Boehme JD and Bruder D.
IL-33: jack-of-all-trades in the orchestration of respiratory antibacterial immunity.
Cell Mol Immunol. 2017 Jul 10. doi: 10.1038/cmi.2017.53. [Epub ahead of print]
Volckmar J, Gereke M, Ebensen T, Riese P, Philipsen L, Lienenklaus S, Wohlleber D, Klopfleisch R, Stegemann-Koniszewski S, Müller AJ, Gruber AD, Knolle P, Guzman CA, Bruder D.
Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.
Sci Rep 2017; DOI: 10.1038/srep43985
Sakthivel P, Breithaupt A, Gereke M, Copland DA, Schulz C, Gruber AD, Dick AD, Schreiber J, Bruder D.
Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients: Potential Implication of the CD200/CD200R Axis in the Disease Course.
Lung. 2017 Feb;195(1):59-68. doi: 10.1007/s00408-016-9962-4.
Mracsko E, Stegemann-Koniszewski S, Na SY, Dalpke A, Bruder D, Lasitschka F, Veltkamp R.
A Mouse Model of Post-Stroke Pneumonia Induced by Intra-Tracheal Inoculation with Streptococcus pneumoniae.
Cerebrovasc Dis. 2017;43(3-4):99-109. doi: 10.1159/000452136. Epub 2017 Jan 4.
Sakthivel P, Bruder D.
Mechanism of granuloma formation in sarcoidosis.
Curr Opin Hematol. 2017 Jan;24(1):59-65.
Parzmair GP, Gereke M, Haberkorn O, Annemann M, Podlasly L, Kliche S, Reinhold A, Schraven B, Bruder D.
ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens.
J Leukoc Biol. 2017 Feb;101(2):407-419. doi: 10.1189/jlb.1A0216-090RR. Epub 2016 Sep 7.
2016
Duvigneau S, Sharma-Chawla N, Boianelli A, Stegemann-Koniszewski S, Nguyen VK, Bruder D, Hernandez-Vargas EA.
Hierarchical effects of pro-inflammatory cytokines on the post-influenza susceptibility to pneumococcal coinfection.
Sci Rep. 2016 Nov 22;6:37045. doi: 10.1038/srep37045.
Pieler MM*, Frentzel S*, Bruder D, Wolff MW, Reichl U.
A cell culture-derived whole virus influenza A vaccine based on magnetic sulfated cellulose particles confers protection in mice against lethal influenza A virus infection.
Vaccine. 2016 Dec 7;34(50):6367-6374. doi: 10.1016/j.vaccine.2016.10.041. *contributed equally.
Sharma-Chawla N, Sender V, Kershaw O, Gruber AD, Volckmar J, Henriques-Normark B, Stegemann-Koniszewski S, Bruder D.
Influenza A virus infection predisposes hosts to secondary infection with different Streptococcus pneumoniae serotypes with similar outcome but serotype-specific manifestation.
Infect. Immun. Accepted manuscript posted online 19 September 2016 , doi:10.1128/IAI.00422-16
Boianelli A, Sharma-Chawla N, Bruder D, Hernandez-Vargas EA.
Oseltamivir PK/PD modelling and simulation to evaluate treatment strategies against Influenza-Pneumococcus coinfection.
Front. Cell. Infect.Microbiol. doi: 10.3389/fcimb.2016.00060
Sakthivel P, Sharma N, Klahn P, Gereke M, Bruder D.
Abscisic acid: a phytohormone and mammalian cytokine as novel pharmacon with potential for future development into clinical applications.
Curr Med Chem. 2016;23(15):1549-70.
Sakthivel P, Breithaupt A, Gereke M, Copland DA, Schulz C, Gruber AD, Dick AD, Schreiber J, Bruder D.
Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients: Potential Implication of the CD200/CD200R Axis in the Disease Course.
Lung. 2016 Nov 18. [Epub ahead of print]
Stegemann-Koniszewski S, Jeron A, Gereke M, Geffers R, Kröger A, Gunzer M, Bruder D.
Alveolar type II epithelial cells contribute to the anti-influenza A virus response in the lung by integrating pathogen- and microenvironment-derived signals.
mBio 7(3):e00276-16. doi:10.1128/mBio.00276-16.
ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo.
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1026-33. doi: 10.1073/pnas.1518836113.
Andzinski L, Kasnitz N, Stahnke S, Wu CF, Gereke M, von Köckritz-Blickwede M, Schilling B, Brandau S, Weiss S, Jablonska J.
Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human.
Int J Cancer. 2016 Apr 15;138(8):1982-93. doi: 10.1002/ijc.29945. Epub 2015 Dec 17.
Patente
Europäische Patentanmeldung 15201000.5: “Kombinierte Aufreinigung und Formulierung von Vakzinen”
M Wolff, M Piehler, S Frentzel, D Bruder, U Reichl. Application pending.
2015
Sakthivel P, Grunewald J, Eklund A, Bruder D*, Wahlström J*.
Pulmonary sarcoidosis is associated with high-level ICOS expression on lung regulatory T cells - possible implications for the ICOS/ICOS-L axis in disease course and Resolution.
Clin Exp Immunol. 2016 Feb;183(2):294-306. doi: 10.1111/cei.12715. Epub 2015 Nov 24. *Senior authors contributed equally.
Boianelli A, Nguyen VK, Ebensen T, Schulze K, Wilk E, Sharma N, Stegemann-Koniszewski S, Bruder D, Toapanta FR, Guzmán CA, Meyer-Hermann M, Hernandez-Vargas EA.
Modeling Influenza Virus - A roadmap for influenza Research.
Viruses. 2015 Oct 12;7(10):5274-304. doi: 10.3390/v7102875.
Tschernig T*, Hartwig C*, Jeron A*, Thai Dinh Q, Gereke M, Bruder D.
First genomic analysis of dendritic cells from lung and draining lymph nodes in murine asthma.
Int J Genomics. 2015;2015:638032. doi: 10.1155/2015/638032. Epub 2015 Feb 24. *first authors contributed equally.
Boehme JD, Pietkiewicz S, Lavrik I, Jeron A, Bruder D.
Morphological and Functional Alterations of Alveolar Macrophages in a Murine Model of Chronic Inflammatory Lung Disease.
Lung. 2015 Aug 30. doi: 10.1007/s00408-015-9797-4 [Epub ahead of print]
Biswas A, Bruder D, Wolf SA, Jeron A, Mack M, Heimesaat MM, Dunay IR.
Ly6Chi monocytes control cerebral toxoplasmosis.
J Immunol. 2015 Apr 1;194(7):3223-35. doi: 10.4049/jimmunol.1402037.
Yeruva S, Chodisetti G, Luo M, Chen M, Cinar A, Ludolph L, Lünnemann M, Goldstein J, Singh AK, Riederer B, Bachmann O, Bleich A, Gereke M, Bruder D, Hagen S, He P, Yun C, Seidler U.
Evidence for a causal link between adaptor protein PDZK1 downregulation and Na+/H + exchanger NHE3 dysfunction in human and murine colitis.
Pflugers Arch. 2015 Aug;467(8):1795-807. doi: 10.1007/s00424-014-1608-x. Epub 2014 Oct 2.
2014
Petzold C, Steinbronn N, Gereke M, Strasser RH, Sparwasser T, Bruder D, Geffers R, Schallenberg S, Kretschmer K.
Fluorochrome-based definition of naturally occurring Foxp3+ regulatory T cells of intra- and extrathymic origin.
Eur J Immunol. 2014; 44(12):3632-45. doi: 10.1002/eji.201444750.
Sakthivel P, Gereke M, Breithaupt A, Fuchs D, Gigliotti L, Gruber AD, Dianzani U, Bruder D.
Attenuation of Immune-Mediated Influenza Pneumonia by Targeting the Inducible Co-Stimulator (ICOS) Molecule on T Cells.
PLoS One. 2014 Jul 16;9(7):e100970. doi: 10.1371/journal.pone.0100970.
Nair S, Michaelsen-Preusse K, Finsterbusch K, Stegemann-Koniszewski S, Bruder D, Grashoff M, Korte M, Köster M, Kalinke U, Hauser J, Kröger A.
Interferon Regulatory Factor-1 Protects from Fatal Neurotropic Infection with Vesicular Stomatitis Virus by Specific Inhibition of Viral Replication in Neurons.
PLOS Pathog. 2014;10(3):DOI: 10.1371/journal.ppat.1003999.
Kominsky DJ, Campbell EL, Ehrentraut SF, Wilson KE, Kelly CJ, Glover LE, Collins CB, Bayless AJ, Saeedi B, Dobrinskikh E, Bowers BE, Macmanus CF, Müller W, Colgan SP, Bruder D.
IFN-γ-Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia.
J Immunol. 2013 Dec 23. doi: 104049/jimmunol.1301757.
2013
Telieps T, Ewald F, Gereke M, Annemann M, Rauter Y, Schuster M, Ueffing N, von Smolinski D, Gruber AD, Bruder D, Schmitz I.
Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection.
Eur J Immunol. 2013 Jun;43(6):1499-510. doi: 10.1002/eji.201242819. Epub 2013 May 2.
Stegemann-Koniszewski S, Gereke M, Orrskog S, Lienenklaus S, Pasche B, Bader SR, Gruber AD, Akira S, Weiss S, Henriques-Normark B, Bruder D*, Gunzer M*. *equal contribution
TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection.
J Innate Immun. 2013;5(1):84-96. doi: 10.1159/000345112.
2012
Gereke M, Autengruber A, Gröbe L, Jeron A, Bruder D, Stegemann-Koniszewski S.
Flow cytometric isolation of primary murine type II alveolar epithelial cells for functional and molecular studies.
J Vis Exp. 2012 Dec 26;(70). doi:pii: 4322. 10.3791/4322.
Jeron A, Hansen W, Ewert F, Buer J, Geffers R and Bruder D.
ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells.
BMC Genomics. 2012, 13:705 doi:10.1186/1471-2164-13-705, published: 17 December 2012
Stegemann-Koniszewski S, Gereke M, Orrskog S, Lienenklaus S, Pasche B, Bader SR, Gruber AD, Akira A, Weiss S, Henriques-Normark B, Bruder D*, Gunzer M*.
TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection.
J Innate Immun. 2013;5(1):84-96. doi: 10.1159/000345112. Epub 2012 Nov 15.*Both senior authors contributed equally to the study.
Albrecht M, Arnhold M, Lingner S, Mahapatra S, Bruder D, Hansen G, Dittrich AM.
IL-4 attenuates pulmonary epithelial cell-mediated suppression of T cell priming.
PLoS One. 2012;7(9):e45916. doi: 10.1371/journal.pone.0045916. Epub 2012 Sep 20.
First insight into the kinome of human regulatory T cells.
PLoS One. 2012;7(7):e40896. Epub 2012 Jul 16.
Tosiek MJ, BaderS, GruberAD, BuerJ, Gereke M, Bruder D.
CD8+ T cells responding to alveolar antigen lack CD25 expression and fail to precipitate autoimmunity.
Am J Respir Cell Mol Biol. 2011-0387OCFirst published online September 13, 2012 as doi:10.1165/rcmb.2011-0387OC.
Therapeutic intervention in cancer and chronic viral infections: Antibody mediated manipulation of PD-1/PD-L1 interaction.
Rev Recent Clin Trials. 2012;7:10-23.
2011
Alberts R, Chen H, Pommerenke C, Smit AB, Spijker S, Williams RW, Geffers R, Bruder D*, and Schughart, K*. *both senior authors contributed equally
Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for autoimmune disease.
BMC Genomics 2011;12:610 doi:10.1186/1471-2164-12-610
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Nature 2011;doi:10.1038/nature10599
Human regulatory T cells in allogenic stem cell transplantation.
Blood. 2011 Sep 29;118(13):e82-92. Epub 2011 Jul 21.
Tosiek MJ, Gruber AD, Hoymann HG, Bader S, Mauel S, Tschernig T, Buer J, Gereke M, Bruder D.
CD4+CD25+Foxp3+ regulatory T cells are dispensable for controlling CD8+ T cell-mediated lung inflammation.
J. Immunol. 2011, Jun 1;186(11):6106-18. Epub 2011 Apr 25.
Cappuccini F, Eldh T, Bruder D, Gereke M, Jastrow H, Schulze-Osthoff K, Fischer U, Köhler D, Stuschke M, Jendrossek V.
New insights into the molecular pathology of radiation-induced pneumopathy.
Radiother Oncol. 2011 Jun 29.
Hasenberg M, Köhler A, Bonifatius S, Jeron A, Gunzer M.
Direct observation of phagocytosis and NET-formation by neutrophils in infected lungs using 2-photon microscopy.
J Vis Exp. 2011 Jun 2;(52). pii: 2659. doi: 10.3791/2659.
LieszA., Zhou,W., Mracskó, E., Karcher, S., Doerr, H., Schwarting, S., Sun, L., Bruder, D., Stegemann, S, Cerwenka, A., Sommer, C, Dalpke, A. and Veltkamp, R.
Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke.
Brain, 2011 Mar; 134 (Pt 3):704-20.
2010
Bar-On L, Birnberg T, Lewis KL, Edelson B, Bruder D, Hildner K, Buer J, Murphy K, Reizis B, Jung S.
CX3CR1pos CD8αpos dendritic cells are a steady state population related to plasmacytoid dendritic cells.
PNAS, 2010 Aug 2 (Epub ahead of print).
Bruns S, Kniemeyer O, Hasenberg M, Aimanianda V, Nietzsche S, Thywissen A, Jeron A, Latgé JP, Brakhage AA, Gunzer M.
Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA.
PLoS Pathog. 2010 Apr 29;6(4):e1000873.
2009
Gereke M, Jung S, Buer J, Bruder D.
Type II alveolar epithelial cells present antigen to CD4+ T cells and induce Foxp3+ regulatory T cells.
Am. J. Resp. Crit. Care Med. 2009. 179(5):344-55. Epub 2008 Dec 18. Cover page.
Stegemann S, Dahlberg S, Kröger A, Gereke M, Bruder D, Henriques-Normark B., Gunzer M.
Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia.
PLoS ONE. 2009. 4(3):e4840.
Srivastava B, Błażejewska P, Hessmann M, Bruder D, Geffers R, Mauel S, Gruber AD, Schughart K.
Host genetic background strongly influences the response to influenza A virus infections.
PLoS ONE 2009.4(3):e4857.
Jeron A, Pfoertner S, Geffers R, Bruder D, Hammerer P, Hoffmann R, Buer J, Schrader JA.
Dysregulation of apoptotic genes contributes to elevated frequencies of regulatory T cells in renal cell carcinoma.
Tumor Biology 2009;30(3):160-70.
Lienenklaus S, Cornitescu M, Zietara N, Lyszkiewicz M, Gekara N, Jablonska J, Edenhofer F, Rajewsky K, Bruder D, Hafner M, Staeheli P, Weiss S.
Novel reporter mouse reveals constitutive and inflammatory expression of IFN-ß in vivo.
J. Immunol. 2009 Sep 1;183(5):3229-36.
Probst-Kepper M, Geffers R, Kröger A, Viegas N, Erck C, Hecht HJ, Lünsdorf H, Roubin R, Moharregh-Khiabani D, Wagner K, Ocklenburg F, Jeron A, Garritsen H, Arstila TP, Kekäläinen E, Balling R, Hauser H, Buer J, Weiss S.
GARP: a key receptor controlling FOXP3 in human regulatory T cells.
J Cell Mol Med. 2009 Sep;13(9B):3343-57. Epub 2009 May 13.
2008
Barth K, Weinhold K, Guenther A, Linge A, Gereke M, Kasper M.
Charaterization of the molecular interaction between ceveolin-1 and the P2X receptors 4 and 7 in E10 mouse lung alveolar epithelial cells.
Int J Biochem Cell Biol. 2008;40(10):2230-9. Epub 2008 Mar 7.
2007
Gereke M, Groebe L, Prettin S, Kasper M, Enelow RI, Buer J, Bruder D.
Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation.
Respiratory Research, 2007. Jul 4; 8:47.
Hansen W, Westendorf AM, Reinwald R, Bruder D, Deppenmeier S, Groebe L, Probst-Kepper M, Gruber AD, Geffers R, Buer J.
Chronic antigen stimulation in vivo induces a distinct population of antigen-specific Foxp3lowCD25- regulatory T cells.
Journal of Immunology, 2007. 179:8059-68.
Ukena SN, Singh A, Dringenberg U, Engelhardt R, Seidler U, Hansen W, Bleich A, Bruder D, Franzke A, Rogler G, Suerbaum S, Buer J, Gunzer F, Westendorf AM.
Probiotic Escherichia coli Nissle 1917 Inhibits Leaky Gut by Enhancing Mucosal Integrity.
PLoS ONE, 2007. 12;2(12):e1308.
2006
Bruder D, Nussbaum AK, Gakamsky DM, Schirle M, Stevanovic S, Singh-Jasuja H, Schild H, Darji A, Chakraborty T, Pecht I, Wehland J, Weiss S.
Multiple synergizing factors contribute to the strength of the CD8+ T cell response against listeriolysin O.
International Immunology, 2006. 18(1): 89-100.
Ramana CV, Chintapalli J, Xu L, Alia C, Bruder D, Enelow R.
Lung epithelial Stat1 and NF-κB signalling in response to CD8+ T cell antigen recognition.
Journal of Interferon & Cytokine Research, 2006. 26:318-327.
Hansen W, Loser K, Westendorf AM, Bruder D, Siewert C, Huehn J, Beissert S, Buer J.
GPR83-overexpression in naïve CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo.
Journal of Immunology, 2006. 177:209-215.
Westendorf AM, Fleissner D, Deppenmeier S, Gruber AD, Bruder D, Hansen H, Liblau R, Buer J.
Autoimmune-mediated intestinal inflammation - impact and regulation of antigen specific CD8+ T cells.
Gastroenterology, 2006. 131(2):510-24.
Westendorf AM, Bruder D, Hansen W, Buer J.
Intestinal epithelial antigen induces CD4+ T cells with regulatory phenotype in a transgenic autoimmune mouse model.
Ann N Y Acad Sci., 2006. 1072:401-406.
Pfoertner S, Jeron A, Probst-Kepper M, Guzman CA, Hansen W, Westendorf AM, Toepfer T, Schrader AJ, Franzke A, Buer J, Geffers R.
Signatures of human regulatory T cells: an encounter with old friends and new players.
Genome Biol. 2006;7(7):R54.
Bruder D, Srikiatkhachorn A, Enelow,RI.
Cellular Immunity and Lung Injury in Respiratory Virus Infection. Review.
Viral Immunology, 2006. 26:318-327.
2005
Westendorf AM, Templin M, Geffers R, Deppenmeier S, Gruber AD, Probst-Kepper M, Hansen W, Liblau RS, Gunzer F, Bruder D, Buer J.
CD4+ T cell mediated intestinal immunity: chronic inflammation versus immune reaction.
Gut. 2005;54:60-69.
Westerndorf AM, Gunzer F, Deppenmeier S, Tapadar D, Hunger JK, Schmidt MA, Buer J, Bruder D.
Intestinal immunity of E. coli NISSLE 1917: A safe carrier for therapeutic molecules.
FEMS Immunol Med Microbiol. 2005;43:373-384.
Rharbaoui F, Bruder D, Vidakovic M, Ebensen T, Buer J, Guzman C.
Characterization of a B220+ lymhoid cell subpopulation with immune modulatory functions in nasal-associated lymphoid tissues.
J Immunol. 2005;174:1317-1324.
Bruder D, Westendorf AM, Hansen W, Prettin S, Gruber AD, Qian Y, von Boehmer H, Mahnke K, Buer J.
On the edge of autoimmunity: T cell stimulation by steady state dendritic cells prevents autoimmune diabetes.
Diabetes. 2005;54:3395-3401.
2004
Bruder D, Probst-Kepper M, Westendorf AM, Geffers R, Beissert S, Loser K, von Boehmer H, Buer J, Hansen W.
Neuropilin-1 - a surface marker of regulatory T-cells.
Eur. J. Immunol. 2004. 34: 623-630. IF = 4.9 (Faculty of 1000 Biology evaluated: must read).
Bruder D, Westendorf AM, Geffers R, Gruber AD, Gereke M, Enelow R, Buer J.
CD4 T lymphocyte-mediated lung disease: steady state between pathological and tolerogenic immune reactions.
Am. J. Respir. Crit. Care Med. 2004. 170: 1145-1152. IF = 10.7
